Formation of diclofenac molecular ions as the effect of Cu2+-π interaction under electrospray ionization mass spectrometry conditions

被引：4

作者：

Ostrowski, Wojciech ^{[1
]}

Linko, Katarzyna ^{[1
]}

Franski, Rafat ^{[1
]}

机构：

[1] Adam Mickiewicz Univ, Fac Chem, PL-60780 Poznan, Poland

来源：

EUROPEAN JOURNAL OF MASS SPECTROMETRY | 2012年 / 18卷 / 01期

关键词：

diclofenac; copper complexes; cation-pi interactions; electrospray ionisation mass spectrometry; CATION-PI INTERACTIONS; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; TRANSITION-METAL-COMPLEXES; RADICAL CATIONS; GAS-PHASE; COPPER(II); BINDING; ACIDS; DNA;

D O I：

10.1255/ejms.1166

中图分类号：

O64 [物理化学（理论化学）、化学物理学]; O56 [分子物理学、原子物理学];

学科分类号：

070203 ; 070304 ; 081704 ; 1406 ;

摘要：

Solutions containing diclofenac (M) and a copper salt (CuCl2, Cu(ClO4)(2), Cu(NO(3)l(2), CuSO4) were analysed by electrospray ionisation mass spectrometry (ESI-MS). Because of the cation-pi interactions in diclofenac-Cu(II) complexes, the diclofenac molecular ion NI++ at m/z 295 was formed. It was found that the solvent composition (methanol versus water/methanol) and counter ion strongly affect the M++ ion formation. Formation pathways of ion M++ are discussed.

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页码：43 / 50

页数：8

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