Isolation of alpha,alpha-difluoroketene silyl acetal and its application to asymmetric aldol reactions

被引：64
作者：
Iseki, K
Kuroki, Y
Asada, D
Kobayashi, Y
机构：
[1] MEC Laboratory, Daikin Industries, Ltd., Miyukigaoka, Tsukuba
来源：
TETRAHEDRON LETTERS | 1997年 / 38卷 / 08期
关键词：
D O I：
10.1016/S0040-4039(97)00044-0
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Salt-free alpha,alpha-difluoroketene silyl acetal 1 was prepared in pure form. Aldol reactions of 1 with aldehydes catalyzed by catalytic amounts of chiral Lewis acids 2 and 3 proceeded with excellent enantiomeric excess to give optically active alpha,alpha-difluoro-beta-hydroxy esters 4-11 (up to 98% ee). (C) 1997 Elsevier Science Ltd.
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页码：1447 / 1448
页数：2
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