A sensitive ESI-MS HILIC method for the analysis of acetylcholine and choline

被引：0
|
作者：
Grumbach, ES [1 ]
Diehl, DM [1 ]
Mazzeo, JR [1 ]
机构：
[1] Waters Corp, Milford, MA 01757 USA
来源：
LC GC NORTH AMERICA | 2004年
关键词：
D O I：
暂无
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Hydrophilic interaction chromatography (HILIC) is a useful technique for the retention of polar analytes that offers a difference in selectivity compared to traditional reversed-phase (RP) chromatography. The highly volatile organic mobile phases used in HILIC provide increased electrospray ionization-mass spectrometry (ESI-MS) sensitivity. An Atlantis(TM) HILIC Silica column was used to develop a quantitative HILIC LC-MS method for the analysis of acetylcholine and choline. A limit of detection of 0.1 ng/mL was achieved for acetylcholine on a single quadrupole mass spectrometer.
引用
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页码：74 / 75
页数：2
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