As soon as possible in IgE-cow's milk allergy immunotherapy

被引：24

作者：

Bone Calvo, Javier ^{[1
]}

Clavero Adell, Marcos ^{[1
]}

Guallar Abadia, Isabel ^{[1
]}

Laliena Aznar, Sara ^{[1
]}

Sancho Rodriguez, Maria Luisa ^{[1
]}

Claver Monzon, Angela ^{[2
]}

Aliaga Mazas, Yolanda ^{[1
]}

机构：

[1] Miguel Servet Univ Hosp, Pediat Allergy Unit, Paseo Isabel Catolica 1-3, Zaragoza 50009, Spain

[2] Hosp Univ Dexeus, Pediat, Barcelona, Spain

来源：

EUROPEAN JOURNAL OF PEDIATRICS | 2021年 / 180卷 / 01期

关键词：

Cow's milk allergy; Oral immunotherapy; Oral food challenge; Children; ORAL IMMUNOTHERAPY; NATURAL-HISTORY; FOOD ALLERGY; CHILDREN;

D O I：

10.1007/s00431-020-03731-3

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Oral immunotherapy is a common treatment in cow's milk protein allergy. The Department of Pediatric Allergology at the Children's Hospital of Zaragoza performed a retrospective analysis of 335 infants under 1 year of age diagnosed with IgE-mediated cow's milk and early treated. Clinical evaluation, skin prick test, and serum-specific IgE level control were performed before starting and after finishing treatment. Upon completion of treatment, more than 98% of patients became tolerant to milk and no one presented serious adverse reactions. Nowadays, the remaining non-tolerant patients (1.8%) can take milk or derivatives daily-as prophylaxis-to a certain maximum dose and still remain asymptomatic. After immunotherapy, both positive skin prick tests and a progressive decrease in specific IgE levels were found, as desensitization to milk increased. Conclusion: Oral immunotherapy is a safe and effective treatment against allergy to cow's milk proteins in infants. Such treatment should be offered to the children's families from the first moment of diagnosis.

引用

页码：291 / 294

页数：4

共 12 条

[1] Early oral immunotherapy in infants with cow's milk protein allergy [J].

Berti, Irene ;

Badina, Laura ;

Cozzi, Giorgio ;

Giangreco, Manuela ;

Bibalo, Cristina ;

Ronfani, Luca ;

Barbi, Egidio ;

Ventura, Alessandro ;

Longo, Giorgio .

PEDIATRIC ALLERGY AND IMMUNOLOGY, 2019, 30 (05) :572-574

[2] Food allergy in childhood [J].

Clark, AT ;

Ewan, PW .

ARCHIVES OF DISEASE IN CHILDHOOD, 2003, 88 (01) :79-81

[3] Anaphylaxis in children and adolescents: The European Anaphylaxis Registry [J].

Grabenhenrich, Linus B. ;

Doelle, Sabine ;

Moneret-Vautrin, Anne ;

Koehli, Alice ;

Lange, Lars ;

Spindler, Thomas ;

Rueff, Franziska ;

Nemat, Katja ;

Maris, Ioana ;

Roumpedaki, Eirini ;

Scherer, Kathrin ;

Ott, Hagen ;

Reese, Thomas ;

Mustakov, Tihomir ;

Lang, Roland ;

Fernandez-Rivas, Montserrat ;

Kowalski, Marek L. ;

Bilo, Maria B. ;

Hourihane, Jonathan O'B. ;

Papadopoulos, Nikolaos G. ;

Beyer, Kirsten ;

Muraro, Antonella ;

Worm, Margitta .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2016, 137 (04) :1128-+

[4] Specific oral tolerance induction in children with very severe cow's milk-induced reactions [J].

Longo, Giorgio ;

Barbi, Egidio ;

Berti, Irene ;

Meneghetti, Rosanna ;

Pittalis, Angela ;

Ronfani, Luca ;

Ventura, Alessandro .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2008, 121 (02) :343-347

[5] Oral immunotherapy for food allergy: A Spanish guideline. Egg and milk immunotherapy Spanish guide (ITEMS GUIDE). Part 2: Maintenance phase of cow milk (CM) and egg oral immunotherapy (01T), special treatment dosing schedules. Models of dosing schedules of OIT with CM and EGG* [J].

Martorell, A. ;

Alonso, E. ;

Echeverria, L. ;

Escudero, C. ;

Garcia-Rodriguez, R. ;

Blasco, C. ;

Bone, J. ;

Borja-Segade, J. ;

Bracamonte, T. ;

Claver, A. ;

Corzo, J. L. ;

De la Hoz, B. ;

Del Olmo, R. ;

Dominguez, O. ;

Fuentes-Aparicio, V. ;

Guallar, I. ;

Larramona, H. ;

Martin-Munoz, F. ;

Matheu, V. ;

Michavila, A. ;

Ojeda, I. ;

Ojeda, P. ;

Piquer, M. ;

Poza, P. ;

Reche, M. ;

Rodriguez del Rio, P. ;

Rodriguez, M. ;

Ruano, F. ;

Sanchez-Garcia, S. ;

Terrados, S. ;

Valdesoiro, L. ;

Vazquez-Ortiz, M. .

ALLERGOLOGIA ET IMMUNOPATHOLOGIA, 2017, 45 (05) :508-518

[6] Oral desensitization as a useful treatment in 2-year-old children with cow's milk allergy [J].

Martorell, A. ;

De la Hoz, B. ;

Ibanez, M. D. ;

Bone, J. ;

Terrados, M. S. ;

Michavila, A. ;

Plaza, A. M. ;

Alonso, E. ;

Garde, J. ;

Nevot, S. ;

Echeverria, L. ;

Santana, C. ;

Cerda, J. C. ;

Escudero, C. ;

Guallar, I. ;

Piquer, M. ;

Zapatero, L. ;

Ferre, L. ;

Bracamonte, T. ;

Muriel, A. ;

Martinez, M. I. ;

Felix, R. .

CLINICAL AND EXPERIMENTAL ALLERGY, 2011, 41 (09) :1297-1304

[7]

Calatayud CM, 2014, J INVEST ALLERG CLIN, V24, P298

[8] EAACI Guidelines on allergen immunotherapy: IgE-mediated food allergy [J].

Pajno, G. B. ;

Fernandez-Rivas, M. ;

Arasi, S. ;

Roberts, G. ;

Akdis, C. A. ;

Alvaro-Lozano, M. ;

Beyer, K. ;

Bindslev-Jensen, C. ;

Burks, W. ;

Ebisawa, M. ;

Eigenmann, P. ;

Knol, E. ;

Nadeau, K. C. ;

Poulsen, L. K. ;

van Ree, R. ;

Santos, A. F. ;

du Toit, G. ;

Dhami, S. ;

Nurmatov, U. ;

Boloh, Y. ;

Makela, M. ;

O'Mahony, L. ;

Papadopoulos, N. ;

Sackesen, C. ;

Agache, I. ;

Angier, E. ;

Halken, S. ;

Jutel, M. ;

Lau, S. ;

Pfaar, O. ;

Ryan, D. ;

Sturm, G. ;

Varga, E. -M. ;

van Wijk, R. G. ;

Sheikh, A. ;

Muraro, A. .

ALLERGY, 2018, 73 (04) :799-815

[9] Incidence and natural history of challenge-proven cow's milk allergy in European children - EuroPrevall birth cohort [J].

Schoemaker, A. A. ;

Sprikkelman, A. B. ;

Grimshaw, K. E. ;

Roberts, G. ;

Grabenhenrich, L. ;

Rosenfeld, L. ;

Siegert, S. ;

Dubakiene, R. ;

Rudzeviciene, O. ;

Reche, M. ;

Fiandor, A. ;

Papadopoulos, N. G. ;

Malamitsi-Puchner, A. ;

Fiocchi, A. ;

Dahdah, L. ;

Sigurdardottir, S. Th ;

Clausen, M. ;

Stanczyk-Przyluska, A. ;

Zeman, K. ;

Mills, E. N. C. ;

McBride, D. ;

Keil, T. ;

Beyer, K. .

ALLERGY, 2015, 70 (08) :963-972

[10] The natural history of IgE-mediated cow's milk allergy [J].

Skripak, Justin M. ;

Matsui, Elizabeth C. ;

Mudd, Kim ;

Wood, Robert A. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2007, 120 (05) :1172-1177

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