Genetic Basis of Antibiotic Resistance in Pathogenic Acinetobacter Species

被引：132
|
作者：
Poirel, Laurent [1 ]
Bonnin, Remy A. [1 ]
Nordmann, Patrice [1 ]
机构：
[1] Univ Paris 11, INSERM, S Paris Med Sch, Serv Bacteriol Virol,Hop Bicetre,U914, F-94275 K Bicetre, France
来源：
IUBMB LIFE | 2011年 / 63卷 / 12期
关键词：
antibiotic resistance; beta-lactamases; carbapenem resistance; integrons; resistance islands; transposons; SPECTRUM-BETA-LACTAMASE; GRAM-NEGATIVE BACTERIA; CARBAPENEM RESISTANCE; MULTIDRUG-RESISTANCE; BAUMANNII; EXPRESSION; EMERGENCE; CEPHALOSPORINASE; BLA(OXA-23); MECHANISMS;
D O I：
10.1002/iub.532
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Antibiotic resistance in Acinetobacter spp., particularly Acinetobacter baumannii, is increasing rapidly. A. baumannii possesses two intrinsic beta-lactamase genes, in addition to weak permeability and efflux systems, that together confer a natural reduced susceptibility to antibiotics. In addition, numerous acquired mechanisms of resistance have been identified in A. baumannii. The very high genetic plasticity of A. baumannii allows an accumulation of resistance determinants that give rise to multidrug resistance at an alarming rate. The role of novel genetic elements, such as resistance islands, in concentrating antibiotic resistance genes in A. baumannii requires detailed investigation in the near future. (C) 2011 IUBMB IUBMB Life, 63(12): 1061-1067, 2011
引用
收藏
页码：1061 / 1067
页数：7
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