Changes in regulation of cell-cell adhesion during tumor transformation

被引：85

作者：

Gloushankova, N. A. ^{[1
]}

机构：

[1] Russian Acad Med Sci, Blokhin Canc Res Ctr, Moscow 115478, Russia

来源：

BIOCHEMISTRY-MOSCOW | 2008年 / 73卷 / 07期

关键词：

cell-cell adherens junctions; cadherins; actin cytoskeleton; epithelial-mesenchymal transformation;

D O I：

10.1134/S000629790807002X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cadherin-mediated cell-cell adhesion defines the integrity of most tissues. Cell-cell adherens junctions are dynamic structures whose functional state is regulated by interactions of cadherin with beta-catenin, p120, and actin cytoskeleton structures. Small GTPases of the Rho family and GTPase Rap1 play the central role in the formation and maintenance of cell-cell adhesion. Aberrant activation of signaling pathways, transcriptional repression of the E-cadherin gene, ectopic expression of N-cadherin, and disturbances in regulation of adhesive and transcriptional functions of beta-catenin stimulate tumor progression.

引用

页码：742 / 750

页数：9

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