The History of the Molybdenum Cofactor-A Personal View

被引:24
作者
Mendel, Ralf R. [1 ]
机构
[1] Tech Univ Carolo Wilhelmina Braunschweig, Inst Plant Biol, Humboldtstr 1, D-38106 Braunschweig, Germany
来源
MOLECULES | 2022年 / 27卷 / 15期
关键词
molybdenum; molybdenum cofactor biosynthesis; molybdopterin; nitrate reductase; gephyrin; ESCHERICHIA-COLI K-12; MOLYBDOPTERIN GUANINE DINUCLEOTIDE; ASSIMILATORY NITRATE REDUCTASE; MUTANT-CELL LINES; BIOCHEMICAL-CHARACTERIZATION; XANTHINE-OXIDASE; NEUROSPORA-CRASSA; SULFITE OXIDASE; NICOTIANA-TABACUM; PROTEIN GEPHYRIN;
D O I
10.3390/molecules27154934
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The transition element molybdenum (Mo) is an essential micronutrient for plants, animals, and microorganisms, where it forms part of the active center of Mo enzymes. To gain biological activity in the cell, Mo has to be complexed by a pterin scaffold to form the molybdenum cofactor (Moco). Mo enzymes and Moco are found in all kingdoms of life, where they perform vital transformations in the metabolism of nitrogen, sulfur, and carbon compounds. In this review, I recall the history of Moco in a personal view, starting with the genetics of Moco in the 1960s and 1970s, followed by Moco biochemistry and the description of its chemical structure in the 1980s. When I review the elucidation of Moco biosynthesis in the 1990s and the early 2000s, I do it mainly for eukaryotes, as I worked with plants, human cells, and filamentous fungi. Finally, I briefly touch upon human Moco deficiency and whether there is life without Moco.
引用
收藏
页数:25
相关论文
共 159 条
[1]   MOLYBDENUM COFACTOR FROM TOBACCO CELL-CULTURES AND MILK XANTHINE-OXIDASE - INVOLVEMENT OF SULFHYDRYL-GROUPS IN DIMERIZATION ACTIVITY OF COFACTOR [J].
ALIKULOV, ZA ;
MENDEL, RR .
BIOCHEMIE UND PHYSIOLOGIE DER PFLANZEN, 1984, 179 (08) :693-705
[2]   Comparison of the sequences of the Aspergillus nidulans hxB and Drosophila melanogaster ma-I genes with nifS from Azotobacter vinelandii suggests a mechanism for the insertion of the terminal sulphur atom in the molybdopterin cofactor [J].
Amrani, L ;
Primus, J ;
Glatigny, A ;
Arcangeli, L ;
Scazzocchio, C ;
Finnerty, V .
MOLECULAR MICROBIOLOGY, 2000, 38 (01) :114-125
[3]   IDENTIFICATION OF THE MOLYBDENUM COFACTOR IN CHLORATE-RESISTANT MUTANTS OF ESCHERICHIA-COLI [J].
AMY, NK .
JOURNAL OF BACTERIOLOGY, 1981, 148 (01) :274-282
[4]  
Bacher A., 1991, CHEM BIOCH FLAVOENZY, V1, P215
[5]   Pterin chemistry and its relationship to the molybdenum cofactor [J].
Basu, Partha ;
Burgmayer, Sharon J. N. .
COORDINATION CHEMISTRY REVIEWS, 2011, 255 (9-10) :1016-1038
[6]   The bioinorganic chemistry of tungsten [J].
Bevers, Loes E. ;
Hagedoorn, Peter-Leon ;
Hagen, Wilfred R. .
COORDINATION CHEMISTRY REVIEWS, 2009, 253 (3-4) :269-290
[7]   ABA3 is a molybdenum cofactor sulfurase required for activation of aldehyde oxidase and xanthine dehydrogenase in Arabidopsis thaliana [J].
Bittner, F ;
Oreb, M ;
Mendel, RR .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (44) :40381-40384
[8]   The complete genome sequence of Escherichia coli K-12 [J].
Blattner, FR ;
Plunkett, G ;
Bloch, CA ;
Perna, NT ;
Burland, V ;
Riley, M ;
ColladoVides, J ;
Glasner, JD ;
Rode, CK ;
Mayhew, GF ;
Gregor, J ;
Davis, NW ;
Kirkpatrick, HA ;
Goeden, MA ;
Rose, DJ ;
Mau, B ;
Shao, Y .
SCIENCE, 1997, 277 (5331) :1453-+
[9]  
Bortels H., 1930, Arch. Mikrobiol, V1, P333, DOI [10.1007/BF00510471, DOI 10.1007/BF00510471]
[10]   Synthesis of the organic ligand of the molybdenum cofactor, in protected form [J].
Bradshaw, B ;
Dinsmore, A ;
Ajana, W ;
Collison, D ;
Garner, CD ;
Joule, JA .
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 2001, (24) :3239-3244