Mendelian Randomization: Application to Cardiovascular Disease

被引：42
作者：
Timpson, Nicholas J. [1 ]
Wade, Kaitlin H. [1 ]
Smith, George Davey [1 ]
机构：
[1] MRC CAiTE Ctr, Sch Social & Community Med, Bristol BS8 2BN, Avon, England
来源：
CURRENT HYPERTENSION REPORTS | 2012年 / 14卷 / 01期
基金：
英国医学研究理事会;
关键词：
Cardiovascular disease; Hypertension; Risk factor; Confounding; Genetic epidemiology; Causality; Mendelian randomization; Genetics; Body mass index; Lipids; Lipoproteins; Alcohol intake; Inflammation; C-REACTIVE PROTEIN; GENOME-WIDE ASSOCIATION; SINGLE-NUCLEOTIDE POLYMORPHISMS; LIPOPROTEIN CHOLESTEROL LEVELS; HIGH-DENSITY-LIPOPROTEIN; ISCHEMIC-HEART-DISEASE; BLOOD-PRESSURE; GENETIC-VARIANTS; LUNG-CANCER; MYOCARDIAL-INFARCTION;
D O I：
10.1007/s11906-011-0242-7
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
In the absence of an ethical, practical, and economical randomized trial, the epidemiologist is left to explore other methods in efforts to assert causality. An approach based on genotypic variation has the potential to mitigate against some of the problems found within conventional observational studies. Genetic variations associated with risk factors of interest at the population level can be used as proxy measures for these risk factors and to generate estimates of causal effect. The potential and the possible limitations of this approach within the cardiovascular field are presented in this review.
引用
收藏
页码：29 / 37
页数：9
相关论文
共 104 条
  • [31] He FJ., 2004, COCHRANE DB SYST REV, V3, P004937, DOI DOI 10.1002/14651858.CD004937
  • [32] Genome-Wide Association Studies of Plasma Lipids Have We Reached the Limit?
    Hegele, Robert A.
    [J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2010, 30 (11) : 2084 - 2086
  • [33] Nature's randomised trials
    Hingorani, A
    Humphries, S
    [J]. LANCET, 2005, 366 (9501) : 1906 - 1908
  • [34] A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25
    Hung, Rayjean J.
    Mckay, James D.
    Gaborieau, Valerie
    Boffetta, Paolo
    Hashibe, Mia
    Zaridze, David
    Mukeria, Anush
    Szeszenia-Dabrowska, Neonilia
    Lissowska, Jolanta
    Rudnai, Peter
    Fabianova, Eleonora
    Mates, Dana
    Bencko, Vladimir
    Foretova, Lenka
    Janout, Vladimir
    Chen, Chu
    Goodman, Gary
    Field, John K.
    Liloglou, Triantafillos
    Xinarianos, George
    Cassidy, Adrian
    McLaughlin, John
    Liu, Geoffrey
    Narod, Steven
    Krokan, Hans E.
    Skorpen, Frank
    Elvestad, Maiken Bratt
    Hveem, Kristian
    Vatten, Lars
    Linseisen, Jakob
    Clavel-Chapelon, Francoise
    Vineis, Paolo
    Bueno-de-Mesquita, H. Bas
    Lund, Eiliv
    Martinez, Carmen
    Bingham, Sheila
    Rasmuson, Torgny
    Hainaut, Pierre
    Riboli, Elio
    Ahrens, Wolfgang
    Benhamou, Simone
    Lagiou, Pagona
    Trichopoulos, Dimitrios
    Holcatova, Ivana
    Merletti, Franco
    Kjaerheim, Kristina
    Agudo, Antonio
    Macfarlane, Gary
    Talamini, Renato
    Simonato, Lorenzo
    [J]. NATURE, 2008, 452 (7187) : 633 - 637
  • [35] Hepatic Lipase, Genetically Elevated High-Density Lipoprotein, and Risk of Ischemic Cardiovascular Disease
    Johannsen, Trine Holm
    Kamstrup, Pia R.
    Andersen, Rolf V.
    Jensen, Gorm B.
    Sillesen, Henrik
    Tybaerg-Hansen, Anne
    Nordestgaard, Borge G.
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2009, 94 (04) : 1264 - 1273
  • [36] Jurgens G, 2004, COCHRANE DB SYST REV, DOI [10.1002/14651858.CD004022.pub2, DOI 10.1002/14651858.CD004022.PUB2]
  • [37] Extreme lipoprotein(a) levels and risk of myocardial infarction in the general population
    Kamstrup, Pia R.
    Benn, Marianne
    Tybjaerg-Hansen, Anne
    Nordestgaard, Borge G.
    [J]. CIRCULATION, 2008, 117 (02) : 176 - 184
  • [38] Genetically Elevated Lipoprotein(a) and Increased Risk of Myocardial Infarction
    Kamstrup, Pia R.
    Tybjaerg-Hansen, Anne
    Steffensen, Rolf
    Nordestgaard, Borge G.
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2009, 301 (22): : 2331 - 2339
  • [39] DIABETES AND CARDIOVASCULAR-DISEASE - FRAMINGHAM-STUDY
    KANNEL, WB
    MCGEE, DL
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1979, 241 (19): : 2035 - 2038
  • [40] C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis
    Kaptoge, Stephen
    Di Angelantonio, Emanuele
    Lowe, Gordon
    Pepys, Mark B.
    Thompson, Simon G.
    Collins, Rory
    Danesh, John
    Tipping, R. W.
    Ford, C. E.
    Pressel, S. L.
    Walldius, G.
    Jungner, I.
    Folsom, A. R.
    Chambless, L.
    Ballantyne, C. M.
    Panagiotakos, D.
    Pitsavos, C.
    Chrysohoou, C.
    Stefanadis, C.
    Knuiman, M. W.
    Goldbourt, U.
    Benderly, M.
    Tanne, D.
    Whincup, P.
    Wannamethee, S. G.
    Morris, R. W.
    Kiechl, S.
    Willeit, J.
    Mayr, A.
    Schett, G.
    Wald, N.
    Ebrahim, S.
    Lawlor, D.
    Yarnell, J.
    Gallacher, J.
    Casiglia, E.
    Tikhonoff, V.
    Nietert, P. J.
    Sutherland, S. E.
    Bachman, D. L.
    Keil, J. E.
    Cushman, M.
    Psaty, B. M.
    Tracy, R.
    Tybjaerg-Hansen, A.
    Nordestgaard, B. G.
    Zacho, J.
    Frikke-Schmidt, R.
    Giampaoli, S.
    Palmieri, L.
    [J]. LANCET, 2010, 375 (9709) : 132 - 140
12345678910