Mendelian Randomization: Application to Cardiovascular Disease

被引：45

作者：

Timpson, Nicholas J. ^{[1
]}

Wade, Kaitlin H. ^{[1
]}

Smith, George Davey ^{[1
]}

机构：

[1] MRC CAiTE Ctr, Sch Social & Community Med, Bristol BS8 2BN, Avon, England

来源：

CURRENT HYPERTENSION REPORTS | 2012年 / 14卷 / 01期

基金：

英国医学研究理事会;

关键词：

Cardiovascular disease; Hypertension; Risk factor; Confounding; Genetic epidemiology; Causality; Mendelian randomization; Genetics; Body mass index; Lipids; Lipoproteins; Alcohol intake; Inflammation; C-REACTIVE PROTEIN; GENOME-WIDE ASSOCIATION; SINGLE-NUCLEOTIDE POLYMORPHISMS; LIPOPROTEIN CHOLESTEROL LEVELS; HIGH-DENSITY-LIPOPROTEIN; ISCHEMIC-HEART-DISEASE; BLOOD-PRESSURE; GENETIC-VARIANTS; LUNG-CANCER; MYOCARDIAL-INFARCTION;

D O I：

10.1007/s11906-011-0242-7

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

In the absence of an ethical, practical, and economical randomized trial, the epidemiologist is left to explore other methods in efforts to assert causality. An approach based on genotypic variation has the potential to mitigate against some of the problems found within conventional observational studies. Genetic variations associated with risk factors of interest at the population level can be used as proxy measures for these risk factors and to generate estimates of causal effect. The potential and the possible limitations of this approach within the cardiovascular field are presented in this review.

引用

页码：29 / 37

页数：9

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