Identification of the inverted chromosome 16 using chromosome painting

被引：4

作者：

Rao, PN ^{[1
]}

Flejter, WL ^{[1
]}

Rahi, S ^{[1
]}

Li, H ^{[1
]}

Pettenati, MJ ^{[1
]}

机构：

[1] Wake Forest Univ, Sch Med, Dept Pediat, Med Genet Sect, Winston Salem, NC 27157 USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1999年 / 104卷 / 03期

关键词：

AML; AML-M4; inv(16); chromosome; 16; acute leukaemia;

D O I：

10.1046/j.1365-2141.1999.01228.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The inverted chromosome 16 is commonly associated with acute myelomonocytic leukaemia (AML) M4 with bone marrow eosinophilia. Cytogenetic identification of the inverted chromosome 16 can be difficult. To help identify the inversion in bone marrow samples from patients referred for the diagnosis of AML-M4, we applied the molecular cytogenetic technique of chromosome painting using chromosome 16 p-arm paint. The results were concordant with standard chromosome analyses and clearly allowed fur the identification of a pericentric inversion within chromosome 10 even in poor-quality metaphase spreads.

引用

页码：618 / 620

页数：3

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