Chronic Inflammatory Demyelinating Polyneuropathy Due to the Administration of Pegylated Interferon α-2b: A Neuropathology Case Report

被引：7

作者：

Shiga, Kensuke ^{[1
]}

Tanaka, Eijiroh ^{[1
]}

Isayama, Reina ^{[1
]}

Mizuno, Toshiki ^{[1
]}

Itoh, Kyoko ^{[2
]}

Nakagawa, Masanori ^{[1
]}

机构：

[1] Kyoto Prefectural Univ Med, Dept Neurol, Kyoto 602, Japan

[2] Kyoto Prefectural Univ Med, Dept Mol Pathol, Kyoto 602, Japan

来源：

INTERNAL MEDICINE | 2012年 / 51卷 / 02期

关键词：

chronic inflammatory demyelinating polyneuropathy; interferon alpha-2b; adverse effect; immunoglobulin; CHRONIC HEPATITIS-C; VIRUS-INFECTION; ALPHA; THERAPY; POLYRADICULONEUROPATHY; DISORDERS; PATTERNS; NERVE;

D O I：

10.2169/internalmedicine.51.6320

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report a 35-year-old man who developed weakness in his extremities five months after pegylated interferon alpha (IFN alpha)-2b was administered. The serum tumor necrosis factor-alpha (TNF alpha) was elevated and nerve conduction studies revealed demyelination both in the distal and intermediate segments. The sural nerve pathology showed mild demyelinating process. The cessation of IFN alpha and administration of intravenous immunoglobulin improved both his clinical symptoms and the temporal dispersion in motor nerve conduction study. IFN alpha-induced CIDP is presumably a transient immunological condition that requires immunomodulatory therapy. The elevated serum TNFa may implicate the degree of downstream autoimmunitiy induced by IFN alpha.

引用

页码：217 / 221

页数：5

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