Four-order stiffness variation of laser-fabricated photopolymer biodegradable scaffolds by laser parameter modulation

被引：21

作者：

Farkas, Balazs ^{[1
]}

Romano, Ilaria ^{[1
]}

Ceseracciu, Luca ^{[1
]}

Diaspro, Alberto ^{[1
]}

Brandi, Fernando ^{[1
,2
]}

Beke, Szabolcs ^{[1
]}

机构：

[1] Italian Inst Technol, Dept Nanophys, Via Morego 30, I-16163 Genoa, Italy

[2] Ist Nazl Ottica, I-56124 Pisa, Italy

来源：

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2015年 / 55卷

关键词：

Stereolithography; Excimer laser; Biodegradability; Poly(propylene fumarate); Scaffolds; CROSS-LINKING; COMPOSITE SCAFFOLD; DESIGN; STEREOLITHOGRAPHY; FUMARATE);

D O I：

10.1016/j.msec.2015.05.054

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

The effects of various fabrication parameters of our Mask Projection Excimer Laser StereoLithography (MPExSL) system were investigated. We demonstrate that laser parameters directly change the physical properties (stiffness, thermal degradation, and height/thickness) of the poly(propylene fumarate) (PFF) scaffold structures. The tested parameters were the number of pulses, fluence per pulse and laser repetition rate. We present a four-order tuning capability of MPExSL-fabricated structures' stiffness without altering the resin composition or using cumbersome post-treatment procedures. Thermogravimetric analysis and differential scanning calorimetry confirmed this tuning capability. Prototype-segmented scaffold designs are presented and analyzed to further expand the concept and exploit this in situ stiffness tuning capability of the scaffolds for tissue engineering and regenerative medicine applications. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：14 / 21

页数：8

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