Biomimetic fabrication of BCP/COL/HCA scaffolds for bone tissue engineering

被引：27

作者：

Yang, CR ^{[1
]}

Wang, YJ ^{[1
]}

Chen, XF ^{[1
]}

Zhao, NR ^{[1
]}

机构：

[1] S China Univ Technol, Coll Mat Sci & Engn, Key Lab Specially Funct Mat & Adv Mfg Technol, Minist Educ, Guangzhou 510640, Guangdong, Peoples R China

来源：

MATERIALS LETTERS | 2005年 / 59卷 / 28期

基金：

中国国家自然科学基金;

关键词：

calcium phosphate; collagen; scaffold; biomimetic;

D O I：

10.1016/j.matlet.2005.07.022

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

A kind of novel three-dimensional scaffolds for bone tissue engineering was developed using the biomimetic synthesis method combined with sol-gel and freeze-drying techniques. The biodegradable scaffolds were prepared from biphasic calcium phosphate (BCP) as basic materials. Naphthalene was used as porogen and collagen (type I) network matrix was immobilized on the pore walls and surface of the scaffold through freeze-drying and cross-linking with EDC/NHS. The collagen matrix was thought to play an important role in inducing mineralization of hydroxyl-carbonate-apatite (HCA) on the surface of the scaffold. The scaffold was characterized with SEM, EDX and FTIR techniques. The composite scaffold made from BCP and collagen conjugated with carbonate-apatite could be considered as a potential bone tissue engineering implant. (C) 2005 Elsevier B.V. All rights reserved.

引用

页码：3635 / 3640

页数：6

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