N-aroyloxynaphthalimides as novel highly efficient DNA photocleavers:: substituent effects

被引：14

作者：

Qian, XH ^{[1
]}

Yao, W

Chen, G

Huang, XY

Mao, P

机构：

[1] Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116012, Peoples R China

[2] E China Univ Sci & Technol, Inst Pesticides & Pharmaceut, Shanghai 200237, Peoples R China

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 35期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1016/S0040-4039(01)01214-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel DNA photocleaver family of N-benzovloxythioxonaphthalimides. which show improved DNA intercalation and photocleaving activity compared with their oxo- counterparts, were synthesized and evaluated. The substituents on the benzene ring of the benzoyloxy moiety have an important and unusual influence on the DNA photocleaving activity. N-(p-Methoxylbenzovloxy)thioxonaphthalimide is able to photocleave DNA at low concentration (5 muM) with 'time-resolved' and pH independent properties. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：6175 / 6178

页数：4

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