Inhibition of TNF-α stimulated nuclear factor-kappa B (NF-κB) activation by cyclometalated platinum(II) complexes

被引：18

作者：

Liu, Jia

Sun, Raymond Wai-Yin

Leung, Chung-Hang

Lok, Chun-Nam

Che, Chi-Ming ^{[1
]}

机构：

[1] Univ Hong Kong, Dept Chem, State Key Lab Synthet Chem, Hong Kong, Hong Kong, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 02期

关键词：

METAL-COMPLEXES; ANTICANCER; PHOSPHORYLATION; APOPTOSIS; LIGANDS; BINDING; DESIGN; CANCER;

D O I：

10.1039/c1cc15317j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cyclometalated platinum(II) complexes [PtII((CNN)-N-4-N-4)(C NR)]+ ((HCNN)-N-4-N-4 = 6-phenyl-2,2'-bipyridyl) display significant inhibition towards TNF-alpha stimulated NF-kappa B-dependent gene transcription at concentrations down to the micromolar range.

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收藏

页码：230 / 232

页数：3

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