The Complex Interplay Between Cholesterol and Prostate Malignancy

被引：61
作者：
Solomon, Keith R. [1 ]
Freeman, Michael R. [2 ,3 ]
机构：
[1] Harvard Univ, Sch Med, Childrens Hosp Boston,Dept Orthopaed Surg, Enders Res Labs,Urol Dis Res Ctr, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Childrens Hosp Boston, Enders Res Labs,Dept Surg, Boston, MA 02115 USA
[3] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA
来源：
UROLOGIC CLINICS OF NORTH AMERICA | 2011年 / 38卷 / 03期
关键词：
Prostate cancer; Cholesterol; Statins; Steroidogenesis; Castration resistance; CORONARY-HEART-DISEASE; ANDROGEN DEPRIVATION THERAPY; SCANDINAVIAN SIMVASTATIN SURVIVAL; RENAL-TRANSPLANT RECIPIENTS; TOTAL SERUM-CHOLESTEROL; INTIMA-MEDIA THICKNESS; LOW BLOOD CHOLESTEROL; 10-YEAR FOLLOW-UP; I CLINICAL-TRIAL; CANCER-MORTALITY;
D O I：
10.1016/j.ucl.2011.04.001
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Research into the role of cholesterol and prostate disease has been ongoing for many years, but our mechanistic and translational understanding is still poor. Recent evidence indicates that cholesterol-lowering drugs reduce the risk of aggressive prostate cancer. This article reviews the literature on the relationship between circulating cholesterol and prostate cancer. The data strongly point to hypercholesterolemia as a risk factor for prostate cancer progression and suggest clinical opportunities for the use of cholesterol-lowering therapies to alter disease course.
引用
收藏
页码：243 / +
页数：18
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