Chromosomal aneuploidy in the aging brain

被引：38
作者：
Faggioli, Francesca
Vijg, Jan [2 ,3 ]
Montagna, Cristina [1 ,4 ]
机构：
[1] Yeshiva Univ, Albert Einstein Coll Med, Dept Genet, Price Ctr, Bronx, NY 10461 USA
[2] Yeshiva Univ, Albert Einstein Coll Med, Dept Ophthalmol & Visual Sci, Bronx, NY 10461 USA
[3] Yeshiva Univ, Albert Einstein Coll Med, Dept Obstet & Gynecol & Womens Hlth, Bronx, NY 10461 USA
[4] Yeshiva Univ, Albert Einstein Coll Med, Dept Pathol, Bronx, NY 10461 USA
来源：
MECHANISMS OF AGEING AND DEVELOPMENT | 2011年 / 132卷 / 8-9期
关键词：
Aging; Genome integrity; Aneuploidy; Brain; IN-SITU HYBRIDIZATION; PREMATURE CENTROMERE DIVISION; PERIPHERAL-BLOOD LYMPHOCYTES; ALZHEIMERS-DISEASE; GENOME INSTABILITY; PURKINJE NEURONS; FLOW-CYTOMETRY; CELLS; MOSAICISM; CANCER;
D O I：
10.1016/j.mad.2011.04.008
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Mechanisms that govern genome integrity and stability are major guarantors of viability and longevity. As people age, memory and the ability to carry out tasks often decline and their risk for neurodegenerative diseases increases. The biological mechanisms underlying this age-related neuronal decline are not well understood. Genome instability has been implicated in neurodegenerative processes in aging and disease. Aneuploidy, a chromosome content that deviates from a diploid genome, is a recognized form of genomic instability. Here, we will review chromosomal aneuploidy in the aging brain, its possible causes, its consequences for cellular homeostasis and its possible link to functional decline and neuropathies. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：429 / 436
页数：8
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