Comparative genomics of the MHC: Glimpses into the evolution of the adaptive immune system

被引:265
作者
Flajnik, MF [1 ]
Kasahara, M
机构
[1] Grad Univ Adv Studies, Sch Adv Sci, Dept Biosyst Sci, Hayama 2400193, Japan
[2] Univ Maryland, Dept Microbiol & Immunol, Baltimore, MD 21021 USA
关键词
D O I
10.1016/S1074-7613(01)00198-4
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
MHC gene organization (size, complexity, gene order) differs markedly among different species, and yet all nonmammalian vertebrates examined to date have a true "class I region" with tight linkage of genes encoding the class I presenting and processing molecules. Three paralogous regions of the human genome contain sets of linked genes homologous to various loci in the MHC class I, class II, and/or class III regions, providing insight into the organization of the "proto MHC" before the emergence of the adaptive immune system in the jawed vertebrates.
引用
收藏
页码:351 / 362
页数:12
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