Identification of purinergic receptors in retinal ganglion cells

被引：81
作者：
Wheeler-Schilling, TH
Marquordt, K
Kohler, K
Guenther, E
Jabs, R
机构：
[1] Univ Tubingen, Hosp Eye, Dept Pathophysiol Vis & Neuroophthalmol, D-72076 Tubingen, Germany
[2] Univ Bonn, Dept Expt Neurobiol, Clin Neurosurg, D-53105 Bonn, Germany
来源：
MOLECULAR BRAIN RESEARCH | 2001年 / 92卷 / 1-2期
关键词：
P2X receptor; purinergic; ligand-gated channel; ganglion cell; retina; single-cell RT-PCR;
D O I：
10.1016/S0169-328X(01)00160-7
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
P2X receptors are ligand-gated ion channels activated by adenosine triphosphate and expressed in a broad variety of tissues. The present study demonstrates the expression of various types of purinergic P2X receptors in identified retinal ganglion cells (RGCs) of the adult rat retina. Single-cell reverse transcription polymerase chain reaction (SC-RT-PCR) resulted in a positive amplification signal for all P2X receptor subunit mRNAs examined (P2X(3-5), P2X(7)). Immunohistochemistry with P2X(3,4) receptor subunit-specific antibodies showed a labelling of neurons in the ganglion cell layer and inner nuclear layer. Our data suggest that extracellular ATP acts directly on RGCs via several types of P2X receptors and may provide neuromodulatory influences on information processing in the retina. (C) 2001 Elsevier Science BY All rights reserved.
引用
收藏
页码：177 / 180
页数：4
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