Molecular Epidemiology of HIV Type 1 in Singapore and Identification of Novel CRF01_AE/B Recombinant Forms

被引：0

作者：

Oon Tek Ng ^{[1
,2
]}

Munshaw, Supriya ^{[1
]}

Lamers, Susanna L. ^{[3
]}

Chew, Kuan Kiat ^{[2
]}

Lin, Li ^{[2
]}

Redd, Andrew D. ^{[4
]}

Manucci, Jordyn ^{[4
]}

Quinn, Thomas C. ^{[1
,4
]}

Ray, Stuart C. ^{[1
]}

Chua, Arlene ^{[2
]}

Leo, Yee Sin ^{[2
]}

Laeyendecker, Oliver ^{[1
,4
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Baltimore, MD 21205 USA

[2] Tan Tock Seng Hosp, Dept Infect Dis, Singapore, Singapore

[3] BioInfoExperts, Thibodaux, LA USA

[4] NIAID, Immunoregulat Lab, Div Intramural Res, NIH, Baltimore, MD USA

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 2011年 / 27卷 / 10期

关键词：

INJECTING DRUG-USERS; THAILAND; TRANSMISSION; CRF15-01B;

D O I：

10.1089/aid.2010.0364

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To investigate HIV-1 molecular epidemiology in Singapore, we sequenced portions of three regions of the HIV-1 genome (protease HXB2: 2163 to 2620, gp120 HXB2: 6904 to 7628, and gp41 HXB2: 7817 to 8264) from 212 plasma samples collected between February 2008 and August 2009. From these samples, 109 (51.4%) generated interpretable data in all regions. Sixty-one (56.0%) were identified as CRF01_AE, 26 (23.9%) as subtype B and 14 (12.8%) as possible novel recombinant forms. The main novel recombinant pattern, detected in 13 sequences, had subtype B in protease and gp41 and CRF01_AE in gp120. There was intermixing of subtypes within transmission risk groups. However, 85% of subjects infected with the novel recombinant forms self-identified as men who have sex with men or bisexuals compared with only 41% of individuals infected with CRF01_AE and 62% infected with subtype B (p = 0.001).

引用

页码：1135 / 1137

页数：3

共 15 条

[1] [Anonymous], 2010, HIV CIRC REC FORMS C
[2] [Anonymous], NCBI GEN
[3] Drummond A.J., 2014, FigTree 1.4. 2 software
[4] Spatial phylodynamics of HIV-1 epidemic emergence in east Africa
Gray, Rebecca R.
Tatem, Andrew J.
Lamers, Susanna
Hou, Wei
Laeyendecker, Oliver
Serwadda, David
Sewankambo, Nelson
Gray, Ronald H.
Wawer, Maria
Quinn, Thomas C.
Goodenow, Maureen M.
Salemi, Marco
[J]. AIDS, 2009, 23 (14) : F9 - F17
[5] The sequential introduction of HIV-1 subtype B and CRF01_AE in Singapore by sexual transmission: Accelerated V3 region evolution in a subpopulation of Asian CRF01 viruses
Kalish, ML
Korber, BT
Pillai, S
Robbins, KE
Leo, YS
Saekhou, A
Verghese, I
Gerrish, P
Goh, CL
Lupo, D
Tan, BH
Brown, TM
Chan, R
[J]. VIROLOGY, 2002, 304 (02) : 311 - 329
[6] Laeyendecker O, 2005, JAIDS-J ACQ IMM DEF, V38, P356
[7] Primary drug resistance and transmission analysis of HIV-1 in acute and recent drug-naive seroconverters in Singapore
Lee, C. C.
Sun, Y. J.
Barkham, T.
Leo, Y. S.
[J]. HIV MEDICINE, 2009, 10 (06) : 370 - 377
[8] Identification of a Novel Second-Generation Circulating Recombinant Form (CRF48_01B) in Malaysia: A Descendant of the Previously Identified CRF33_01B
Li, Yue
Tee, Kok Keng
Liao, Huanan
Hase, Saiki
Uenishi, Rie
Li, Xiao-Jie
Tsuchiura, Takayo
Yang, Rongge
Govindasamy, Sumathi
Yong, Yean Kong
Tan, Hong Yien
Pybus, Oliver G.
Kamarulzaman, Adeeba
Takebe, Yutaka
[J]. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2010, 54 (02) : 129 - 136
[9] A modified bootscan algorithm for automated identification of recombinant sequences and recombination breakpoints
Martin, DP
Posada, D
Crandall, KA
Williamson, C
[J]. AIDS RESEARCH AND HUMAN RETROVIRUSES, 2005, 21 (01) : 98 - 102
[10] INDEPENDENT INTRODUCTION OF 2 MAJOR HIV-1 GENOTYPES INTO DISTINCT HIGH-RISK POPULATIONS IN THAILAND
OU, CY
TAKEBE, Y
WENIGER, BG
LUO, CC
KALISH, ML
AUWANIT, W
YAMAZAKI, S
GAYLE, HD
YOUNG, NL
SCHOCHETMAN, G
[J]. LANCET, 1993, 341 (8854) : 1171 - 1174

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