Pharmacological classes that extend lifesapn of Caenorhabditis elegans

被引：20
作者：
Carretero, Maria [1 ,2 ,3 ]
Gomez-Amaro, Rafael L. [1 ,2 ,3 ]
Petrascheck, Michael [1 ,2 ,3 ]
机构：
[1] Scripps Res Inst, Dept Physiol Chem, La Jolla, CA 92037 USA
[2] Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA
[3] Scripps Res Inst, Dept Mol & Cellular Neurosci, La Jolla, CA 92037 USA
来源：
FRONTIERS IN GENETICS | 2015年 / 6卷
关键词：
aging; lifespan; pharmacology; GPCR; drug discovery; Caenorhabditis elegans; dietary restriction mimetics; STRESS RESISTANCE; SPAN EXTENSION; DAUER FORMATION; LONGEVITY; DROSOPHILA; REPRODUCTION; RESPIRATION; HEALTHSPAN; INHIBITION; RECEPTOR;
D O I：
10.3389/fgene.2015.00077
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Recent progress in the field of aging has resulted in ever increasing numbers of compounds that extend lifespan in Caenorhabditis elegans. Lifespan extending compounds include metabolites and synthetic compounds, as well as natural products. For many of these compounds, mammalian pharmacology is known, and for some the actual targets have been experimentally identified. In this review, we explore the data available in C. elegans to provide an overview of which pharmacological classes have potential for identification of further compounds that extend lifespan.
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页数：6
相关论文
共 57 条
  • [31] Extension of life-span with superoxide dismutase/catalase mimetics
    Melov, S
    Ravenscroft, J
    Malik, S
    Gill, MS
    Walker, DW
    Clayton, PE
    Wallace, DC
    Malfroy, B
    Doctrow, SR
    Lithgow, GJ
    [J]. SCIENCE, 2000, 289 (5484) : 1567 - 1569
  • [32] Activation of EGL-47, a Gαo-coupled receptor, inhibits function of hermaphrodite-specific motor neurons to regulate Caenorhabditis elegans egg-laying behavior
    Moresco, JJ
    Koelle, MR
    [J]. JOURNAL OF NEUROSCIENCE, 2004, 24 (39) : 8522 - 8530
  • [33] A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans
    Morris, JZ
    Tissenbaum, HA
    Ruvkun, G
    [J]. NATURE, 1996, 382 (6591) : 536 - 539
  • [34] Pharmacological inhibition of NF-κB prolongs lifespan of Drosophila melanogaster
    Moskalev, Alexey
    Shaposhnikov, Mikhail
    [J]. AGING-US, 2011, 3 (04): : 391 - 394
  • [35] Identification of ligands for DAF-12 that govern Dauer formation and reproduction in C. elegans
    Motola, DL
    Cummins, CL
    Rottiers, V
    Sharma, KK
    Li, TT
    Li, Y
    Suino-Powell, K
    Xu, HE
    Auchus, RJ
    Antebi, A
    Mangelsdorf, DJ
    [J]. CELL, 2006, 124 (06) : 1209 - 1223
  • [36] Metformin Induces a Dietary Restriction-Like State and the Oxidative Stress Response to Extend C. elegans Healthspan via AMPK, LKB1, and SKN-1
    Onken, Brian
    Driscoll, Monica
    [J]. PLOS ONE, 2010, 5 (01):
  • [37] Oxenkrug G, 2012, AGING DIS, V3, P352
  • [38] Improving and Accelerating Drug Development for Nervous System Disorders
    Pankevich, Diana E.
    Altevogt, Bruce M.
    Dunlop, John
    Gage, Fred H.
    Hyman, Steve E.
    [J]. NEURON, 2014, 84 (03) : 546 - 553
  • [39] Global mapping of pharmacological space
    Paolini, Gaia V.
    Shapland, Richard H. B.
    van Hoorn, Willem P.
    Mason, Jonathan S.
    Hopkins, Andrew L.
    [J]. NATURE BIOTECHNOLOGY, 2006, 24 (07) : 805 - 815
  • [40] Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases
    Park, Sung-Jun
    Ahmad, Faiyaz
    Philp, Andrew
    Baar, Keith
    Williams, Tishan
    Luo, Haibin
    Ke, Hengming
    Rehmann, Holger
    Taussig, Ronald
    Brown, Alexandra L.
    Kim, Myung K.
    Beaven, Michael A.
    Burgin, Alex B.
    Manganiello, Vincent
    Chung, Jay H.
    [J]. CELL, 2012, 148 (03) : 421 - 433
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