Pharmacological classes that extend lifesapn of Caenorhabditis elegans

被引：20
作者：
Carretero, Maria [1 ,2 ,3 ]
Gomez-Amaro, Rafael L. [1 ,2 ,3 ]
Petrascheck, Michael [1 ,2 ,3 ]
机构：
[1] Scripps Res Inst, Dept Physiol Chem, La Jolla, CA 92037 USA
[2] Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA
[3] Scripps Res Inst, Dept Mol & Cellular Neurosci, La Jolla, CA 92037 USA
来源：
FRONTIERS IN GENETICS | 2015年 / 6卷
关键词：
aging; lifespan; pharmacology; GPCR; drug discovery; Caenorhabditis elegans; dietary restriction mimetics; STRESS RESISTANCE; SPAN EXTENSION; DAUER FORMATION; LONGEVITY; DROSOPHILA; REPRODUCTION; RESPIRATION; HEALTHSPAN; INHIBITION; RECEPTOR;
D O I：
10.3389/fgene.2015.00077
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Recent progress in the field of aging has resulted in ever increasing numbers of compounds that extend lifespan in Caenorhabditis elegans. Lifespan extending compounds include metabolites and synthetic compounds, as well as natural products. For many of these compounds, mammalian pharmacology is known, and for some the actual targets have been experimentally identified. In this review, we explore the data available in C. elegans to provide an overview of which pharmacological classes have potential for identification of further compounds that extend lifespan.
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页数：6
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