Pharmacological classes that extend lifesapn of Caenorhabditis elegans

被引：20
作者：
Carretero, Maria [1 ,2 ,3 ]
Gomez-Amaro, Rafael L. [1 ,2 ,3 ]
Petrascheck, Michael [1 ,2 ,3 ]
机构：
[1] Scripps Res Inst, Dept Physiol Chem, La Jolla, CA 92037 USA
[2] Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA
[3] Scripps Res Inst, Dept Mol & Cellular Neurosci, La Jolla, CA 92037 USA
来源：
FRONTIERS IN GENETICS | 2015年 / 6卷
关键词：
aging; lifespan; pharmacology; GPCR; drug discovery; Caenorhabditis elegans; dietary restriction mimetics; STRESS RESISTANCE; SPAN EXTENSION; DAUER FORMATION; LONGEVITY; DROSOPHILA; REPRODUCTION; RESPIRATION; HEALTHSPAN; INHIBITION; RECEPTOR;
D O I：
10.3389/fgene.2015.00077
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Recent progress in the field of aging has resulted in ever increasing numbers of compounds that extend lifespan in Caenorhabditis elegans. Lifespan extending compounds include metabolites and synthetic compounds, as well as natural products. For many of these compounds, mammalian pharmacology is known, and for some the actual targets have been experimentally identified. In this review, we explore the data available in C. elegans to provide an overview of which pharmacological classes have potential for identification of further compounds that extend lifespan.
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页数：6
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共 57 条
  • [1] Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan
    Alavez, Silvestre
    Vantipalli, Maithili C.
    Zucker, David J. S.
    Klang, Ida M.
    Lithgow, Gordon J.
    [J]. NATURE, 2011, 472 (7342) : 226 - 229
  • [2] Antebi A, 2000, GENE DEV, V14, P1512
  • [3] Remarkable longevity and stress resistance of nematode PI3K-null mutants
    Ayyadevara, Srinivas
    Alla, Ramani
    Thaden, John J.
    Reis, Robert J. Shmookler
    [J]. AGING CELL, 2008, 7 (01) : 13 - 22
  • [4] Bailey CJ., 2004, Pract Diab Int, V21, P115, DOI [10.1002/pdi.606, DOI 10.1002/PDI.606]
  • [5] From lab bench to Wall Street
    Bartfai, Tamas
    [J]. FASEB JOURNAL, 2006, 20 (10) : 1578 - 1580
  • [6] Resveratrol improves health and survival of mice on a high-calorie diet
    Baur, Joseph A.
    Pearson, Kevin J.
    Price, Nathan L.
    Jamieson, Hamish A.
    Lerin, Carles
    Kalra, Avash
    Prabhu, Vinayakumar V.
    Allard, Joanne S.
    Lopez-Lluch, Guillermo
    Lewis, Kaitlyn
    Pistell, Paul J.
    Poosala, Suresh
    Becker, Kevin G.
    Boss, Olivier
    Gwinn, Dana
    Wang, Mingyi
    Ramaswamy, Sharan
    Fishbein, Kenneth W.
    Spencer, Richard G.
    Lakatta, Edward G.
    Le Couteur, David
    Shaw, Reuben J.
    Navas, Placido
    Puigserver, Pere
    Ingram, Donald K.
    de Cabo, Rafael
    Sinclair, David A.
    [J]. NATURE, 2006, 444 (7117) : 337 - 342
  • [7] Compounds that confer thermal stress resistance and extended lifespan
    Benedetti, Michael G.
    Foster, Amanda L.
    Vantipalli, Maithili C.
    White, Mark P.
    Sampayo, James N.
    Gill, Matthew S.
    Olsen, Anders
    Lithgow, Gordon J.
    [J]. EXPERIMENTAL GERONTOLOGY, 2008, 43 (10) : 882 - 891
  • [8] Bharill Puneet, 2013, Frontiers in Genetics, V4, P34, DOI 10.3389/fgene.2013.00034
  • [9] The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR
    Chin, Randall M.
    Fu, Xudong
    Pai, Melody Y.
    Vergnes, Laurent
    Hwang, Heejun
    Deng, Gang
    Diep, Simon
    Lomenick, Brett
    Meli, Vijaykumar S.
    Monsalve, Gabriela C.
    Hu, Eileen
    Whelan, Stephen A.
    Wang, Jennifer X.
    Jung, Gwanghyun
    Solis, Gregory M.
    Fazlollahi, Farbod
    Kaweeteerawat, Chitrada
    Quach, Austin
    Nili, Mahta
    Krall, Abby S.
    Godwin, Hilary A.
    Chang, Helena R.
    Faull, Kym F.
    Guo, Feng
    Jiang, Meisheng
    Trauger, Sunia A.
    Saghatelian, Alan
    Braas, Daniel
    Christofk, Heather R.
    Clarke, Catherine F.
    Teitell, Michael A.
    Petrascheck, Michael
    Reue, Karen
    Jung, Michael E.
    Frand, Alison R.
    Huang, Jing
    [J]. NATURE, 2014, 510 (7505) : 397 - 401
  • [10] Lifespan regulation by evolutionarily conserved genes essential for viability
    Curran, Sean P.
    Ruvkun, Gary
    [J]. PLOS GENETICS, 2007, 3 (04): : 0479 - 0487
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