Serjanic Acid Improves Immunometabolic Markers in a Diet-Induced Obesity Mouse Model

被引：4

作者：

Gutierrez, Gustavo ^{[1
]}

Giraldo-Davila, Deisy ^{[2
]}

Combariza, Marianny Y. ^{[2
]}

Holzgrabe, Ulrike ^{[3
]}

Humberto Tabares-Guevara, Jorge ^{[4
]}

Robinson Ramirez-Pineda, Jose ^{[4
,5
]}

Acin, Sergio ^{[5
,6
]}

Lorena Munoz, Diana ^{[6
]}

Montoya, Guillermo ^{[1
]}

Balcazar, Norman ^{[5
,6
]}

机构：

[1] Univ ICESI, Nat Sci Sch, Pharmaceut Sci Dept, Cali 760031, Colombia

[2] Ind Univ Santander, Sch Chem, Bucaramanga 680003, Santander, Colombia

[3] Univ Wurzburg, Inst Pharm & Food Chem, D-97074 Wurzburg, Germany

[4] Univ Antioquia, Sch Med, Grp Inmunomodulac, Medellin 050010, Antioquia, Colombia

[5] Univ Antioquia, Sch Med, Dept Physiol & Biochem, Carrera 51D 62-29, Medellin 050010, Colombia

[6] Univ Antioquia, Sede Invest Univ, GENMOL Grp, Calle 62 52-59, Medellin 050010, Colombia

来源：

MOLECULES | 2020年 / 25卷 / 07期

关键词：

Cecropia telenitida; serjanic acid; type; 2; diabetes; HIGH-FAT DIET; INSULIN-RESISTANCE; PANCREATIC LIPASE; PENTACYCLIC TRITERPENE; ANTRODIA-CAMPHORATA; ASIATIC ACID; GLUCOSE; COMPOUND; LEPTIN; CELLS;

D O I：

10.3390/molecules25071486

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Plant extracts from Cecropia genus have been used by Latin-American traditional medicine to treat metabolic disorders and diabetes. Previous reports have shown that roots of Cecropia telenitida that contains serjanic acid as one of the most prominent and representative pentacyclic triterpenes. The study aimed to isolate serjanic acid and evaluate its effect in a prediabetic murine model by oral administration. A semi-pilot scale extraction was established and serjanic acid purification was followed using direct MALDI-TOF analysis. A diet induced obesity mouse model was used to determine the impact of serjanic acid over selected immunometabolic markers. Mice treated with serjanic acid showed decreased levels of cholesterol and triacylglycerols, increased blood insulin levels, decreased fasting blood glucose and improved glucose tolerance, and insulin sensitivity. At transcriptional level, the reduction of inflammation markers related to adipocyte differentiation is reported.

引用

页数：15

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