The Impact of Gonadal Hormones on the Expression of Human Neurological Disorders

被引：10

作者：

Schipper, Hyman M. ^{[1
,2
]}

机构：

[1] McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada

[2] McGill Univ, Dept Neurol & Neurosurg, Montreal, PQ, Canada

来源：

NEUROENDOCRINOLOGY | 2016年 / 103卷 / 05期

基金：

加拿大健康研究院;

关键词：

Alzheimer disease; Epilepsy; Estrogen; Menopause; Menses; Movement disorder; Multiple sclerosis; Neoplasm; Oral contraceptive; ESTROGEN-REPLACEMENT THERAPY; MILD COGNITIVE IMPAIRMENT; HYPOTHALAMIC ARCUATE NUCLEUS; OBSTRUCTIVE SLEEP-APNEA; HIGH-DOSE TAMOXIFEN; ALZHEIMERS-DISEASE; PARKINSONS-DISEASE; MULTIPLE-SCLEROSIS; POSTMENOPAUSAL WOMEN; REPRODUCTIVE FACTORS;

D O I：

10.1159/000440620

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effects of gonadal steroids on neurological well-being and disease constitute a rich and rapidly expanding area of basic and clinical neuroscience. Gonadal hormones exert potent effects on monoaminergic, cholinergic and peptidergic pathways as well as neurosteroidogenesis which, in turn, impact normal brain organization and function. A spectrum of human neurological conditions are influenced by hormonal fluctuations associated with the menstrual cycle, pregnancy, the menopause and use of oral contraceptives. An appreciation of these relationships may facilitate the development of specific hormonal and anti-hormonal therapies for neurological disorders as disparate as catamenial epilepsy and acute intermittent porphyria. (C) 2015 S. Karger AG, Basel

引用

页码：417 / 431

页数：15

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