Oxidative Cleavage of Functionalized Cyclic Olefins with H2O2 Using a Peroxotungstate Complex

被引：4

作者：

Ford, Mark J. ^{[1
]}

Kohlhepp, Helmut ^{[1
]}

Miller, Stephen ^{[1
]}

Riess, Sven ^{[1
]}

Schmidt, Jan Peter ^{[1
]}

Wisplinghoff, Lothar ^{[1
]}

机构：

[1] Bayer CropSci AG, D-65926 Frankfurt, Germany

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2011年 / 15卷 / 04期

关键词：

HYDROGEN-PEROXIDE; ADIPIC ACID; CARBOXYLIC-ACIDS;

D O I：

10.1021/op200130d

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The oxidative cleavage of functionalized cyclic olefins with aqueous hydrogen peroxide was studied. A mild protocol was developed using a readily available diperoxotungstate catalyst that allowed otherwise unstable functionalities to be present during the oxidation. During the optimization of the procedure (3R*,4R*)-3-[(benzyloxy)carbonyl]-4-(ethoxycarbonyl)hexanedioic add was synthesized on a 400 g scale furnishing the product in 7996 yield.

引用

页码：883 / 885

页数：3

共 20 条

[1]

Cao FB, 2005, CHINESE J ORG CHEM, V25, P96

[2] Ruthenium-catalyzed oxidation of alkenes, alkynes, and alcohols to organic acids with aqueous hydrogen peroxide [J].