A phenoxazine compound, 2-amino-4,4α-dihydro-4α-7-dimethyl-3H-phenoxazine-3-one reverses the phenylephrine or high-K+ induced contraction of smooth muscles in rat aorta and guinea pig tenia cecum

被引：17

作者：

Musha, S

Watanabe, M

Ishida, Y

Kato, S

Konishi, M

Tomoda, A ^{[1
]}

机构：

[1] Tokyo Med Univ, Dept Biochem, Tokyo 1608402, Japan

[2] Tokyo Med Univ, Intractable Immune Syst Dis Res Ctr, Tokyo 1608402, Japan

[3] Tokyo Med Univ, Dept Physiol, Tokyo 1608402, Japan

[4] Univ Cincinnati, Coll Med, Dept Mol & Cellular Physiol, Cincinnati, OH 45267 USA

[5] Tokyo Med Univ, Dept Internal Med 3, Tokyo 1600023, Japan

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2005年 / 28卷 / 08期

关键词：

smooth muscle; aorta; tenia cecum; phenoxazine;

D O I：

10.1248/bpb.28.1521

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

2-Amino-4,4 alpha-dihydro-4 alpha-7-dimethyl-3H-phenoxazine-3-one (Phx-1) reversed concentration dependently the contraction of both rat aorta and guinea pig tenia cecum induced by phenylephrine or high-K+. Since Phx-1 suppresses the responses of human mononuclear cells to phytohem agglutinin, (Akazawa et al. Tohoku J. Exp. Med., 196, 185-192, 2002), Phx-1 may be useful for developing new vasorelaxing agents with immunosuppressive action.

引用

页码：1521 / 1523

页数：3

共 14 条

[1] Effects of novel phenoxazine compounds, 2-amino-4, 4α-dihydro-4α, 7-dimethyl-3H-phenoxazine-3-one and 3-amino-1,4α-dihydro-4α, 8-dimethyl-2H-phenoxazine-2-one on proliferation of phytohemagglutinin- or anti-human IgM-activated human peripheral blood mononuclear cells [J].