Synthesis of spiro[indane-1,3-dione-1-pyrrolines] via copper-catalyzed heteroannulation of ketoxime acetates with 2-arylideneindane-1,3-diones

被引：29

作者：

Duan, Jindian ^{[1
]}

Cheng, Yuyu ^{[1
]}

Li, Rou ^{[1
]}

Li, Pengfei ^{[1
]}

机构：

[1] South Univ Sci & Technol China, Dept Chem, Shenzhen 518055, Guangdong, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2016年 / 3卷 / 12期

基金：

中国国家自然科学基金;

关键词：

OXIME ESTERS; C-H; 1,3-DIPOLAR CYCLOADDITION; REGIOSELECTIVE SYNTHESIS; ALKENES SYNTHESIS; FREDERICAMYCIN-A; INTERNAL ALKYNES; BOND ACTIVATION; CYCLIZATION; ISOQUINOLINES;

D O I：

10.1039/c6qo00454g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A cuprous cyanide-catalyzed heteroannulation reaction of 2-arylideneindane-1,3-dione with ketoxime acetates has been developed for the synthesis of novel spiro[indane-1,3-dione-1-pyrrolines] through the cleavage of N-O and C-H bonds and formation of C-C and C-N bonds. The synthetic strategy shows broad substrate scope and furnishes spiro[indane-1,3-dione-1-pyrrolines] in high yields.

引用

页码：1614 / 1618

页数：5

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