Pd-Catalyzed para-selective C-H difluoromethylation of aromatic carbonyls

被引：39

作者：

Mao, Yang-Jie ^{[1
]}

Wang, Bing-Xin ^{[1
]}

Wu, Qiu-Zi ^{[1
]}

Zhou, Kun ^{[1
]}

Lou, Shao-Jie ^{[1
]}

Xu, Dan-Qian ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Catalyt Hydrogenat Res Ctr, State Key Lab Breeding Base Green Chem Synth Tech, Hangzhou 310014, Zhejiang, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 14期

关键词：

BENZENE-DERIVATIVES; META; ALKYLATION; ARENES; LIGAND; FUNCTIONALIZATIONS; REGIOSELECTIVITY; PHOSPHONATES; FLUORINATION; BROMINATION;

D O I：

10.1039/c8cc09129c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel palladium catalyzed highly para-selective C-H difluoromethylation of electron-deficient aromatic carbonyls was developed. Diverse substituted aromatic ketones and benzoates were selectively difluoromethylated at the remote para-site of carbonyl groups in moderate to good yields. Moreover, the difuoromethylation was also compatible with several complex bioactive molecules.

引用

页码：2019 / 2022

页数：4

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