Prenatal stress programs lipid metabolism enhancing cardiovascular risk in the female F1, F2, and F3 generation in the primate model common marmoset (Callithrix jacchus)

被引:14
作者
Buchwald, Ulrike [1 ,2 ]
Teupser, Daniel [2 ,3 ]
Kuehnel, Friederike [1 ,2 ]
Grohmann, Jana [1 ]
Schmieder, Nancy [1 ]
Beindorff, Nicola [4 ]
Schlumbohm, Christina [5 ]
Fuhrmann, Herbert [1 ]
Einspanier, Almuth [1 ,2 ]
机构
[1] Univ Leipzig, Fac Vet, Inst Physiol Chem, D-04103 Leipzig, Germany
[2] Univ Leipzig, LIFE Leipzig Res Ctr Civilizat Dis, D-04103 Leipzig, Germany
[3] Univ Hosp Leipzig, Inst Lab Med Clin Chem & Mol Diagnost, Leipzig, Germany
[4] German Primate Ctr, Dept Reprod Biol, Gottingen, Germany
[5] German Primate Ctr, Clin Neurobiol Lab, Gottingen, Germany
关键词
atherosclerosis; cholesterol; dexamethasone; fatty acid; glucocorticoid; high-density lipoprotein; imprinting; lipoprotein; low-density lipoprotein; triglyceride; FATTY-ACID COMPOSITION; LOW-BIRTH-WEIGHT; BLOOD-PRESSURE; FETAL-GROWTH; MONKEY; EXPOSURE; MECHANISMS; PREGNANCY; DISEASE; GLUCOCORTICOIDS;
D O I
10.1111/j.1600-0684.2012.00551.x
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Background Many human diseases are modulated by intrauterine environment, which is called prenatal programming. This study investigated effects of prenatal glucocorticoids on the lipid metabolism of three filial generations of common marmosets. Methods Pregnant primates were treated with dexamethasone during pregnancy. Body weight and blood lipid parameters of adult female offspring (F1: n = 5, F2: n = 6, F3: n = 3) were compared with age-related female controls (n = 12). Results F1, F2, and F3 offspring showed significantly lower percentage of plasma n3 fatty acids than controls. F2 and F3 presented higher cholesterol levels, with significantly more LDL cholesterol, significantly less HDL triglycerides and an enhanced cholesterol/HDL cholesterol ratio. Body weight was not significantly affected. Conclusions Prenatal dexamethasone led to higher amounts of cardiovascular risk factors and less protective parameters in female F1F3 offspring. The intergenerational consequences suggest prenatal programming through epigenetic effects.
引用
收藏
页码:231 / 240
页数:10
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