Nickel-Catalyzed Aromatic C-H Functionalization

被引：72
作者：
Yamaguchi, Junichiro [1 ]
Muto, Kei [1 ]
Itami, Kenichiro [2 ,3 ,4 ]
机构：
[1] Waseda Univ, Dept Appl Chem, Tokyo 1698555, Japan
[2] Nagoya Univ, Inst Transformat Biomol WPI ITbM, Chikusa Ku, Nagoya, Aichi 4648602, Japan
[3] Nagoya Univ, Grad Sch Sci, Chikusa Ku, Nagoya, Aichi 4648602, Japan
[4] Nagoya Univ, JST ERATO, Itami Mol Nanocarbon Project, Chikusa Ku, Nagoya, Aichi 4648602, Japan
来源：
TOPICS IN CURRENT CHEMISTRY | 2016年 / 374卷 / 04期
关键词：
C-H functionalization; C-H activation; Nickel; Heteroarenes; Arenes; Catalyst; UNACTIVATED C(SP(3))-H BONDS; BIDENTATE-CHELATION ASSISTANCE; DIRECT ALKYLATION; ALIPHATIC AMIDES; DIRECT ARYLATION; ACID CATALYSIS; THIOPEPTIDE ANTIBIOTICS; SELECTIVE ALKENYLATION; SYNERGISTIC CATALYSIS; ORGANOZINC REAGENTS;
D O I：
10.1007/s41061-016-0053-z
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Catalytic C-H functionalization using transition metals has received significant interest from organic chemists because it provides a new strategy to construct carbon-carbon bonds and carbon-heteroatom bonds in highly functionalized, complex molecules without pre-functionalization. Recently, inexpensive catalysts based on transition metals such as copper, iron, cobalt, and nickel have seen more use in the laboratory. This review describes recent progress in nickelcatalyzed aromatic C-H functionalization reactions classified by reaction types and reaction partners. Furthermore, some reaction mechanisms are described and cutting-edge syntheses of natural products and pharmaceuticals using nickel-catalyzed aromatic C-H functionalization are presented.
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页数：33
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