Nickel-Catalyzed Aromatic C-H Functionalization

被引：73

作者：

Yamaguchi, Junichiro ^{[1
]}

Muto, Kei ^{[1
]}

Itami, Kenichiro ^{[2
,3
,4
]}

机构：

[1] Waseda Univ, Dept Appl Chem, Tokyo 1698555, Japan

[2] Nagoya Univ, Inst Transformat Biomol WPI ITbM, Chikusa Ku, Nagoya, Aichi 4648602, Japan

[3] Nagoya Univ, Grad Sch Sci, Chikusa Ku, Nagoya, Aichi 4648602, Japan

[4] Nagoya Univ, JST ERATO, Itami Mol Nanocarbon Project, Chikusa Ku, Nagoya, Aichi 4648602, Japan

来源：

TOPICS IN CURRENT CHEMISTRY | 2016年 / 374卷 / 04期

关键词：

C-H functionalization; C-H activation; Nickel; Heteroarenes; Arenes; Catalyst; UNACTIVATED C(SP(3))-H BONDS; BIDENTATE-CHELATION ASSISTANCE; DIRECT ALKYLATION; ALIPHATIC AMIDES; DIRECT ARYLATION; ACID CATALYSIS; THIOPEPTIDE ANTIBIOTICS; SELECTIVE ALKENYLATION; SYNERGISTIC CATALYSIS; ORGANOZINC REAGENTS;

D O I：

10.1007/s41061-016-0053-z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Catalytic C-H functionalization using transition metals has received significant interest from organic chemists because it provides a new strategy to construct carbon-carbon bonds and carbon-heteroatom bonds in highly functionalized, complex molecules without pre-functionalization. Recently, inexpensive catalysts based on transition metals such as copper, iron, cobalt, and nickel have seen more use in the laboratory. This review describes recent progress in nickelcatalyzed aromatic C-H functionalization reactions classified by reaction types and reaction partners. Furthermore, some reaction mechanisms are described and cutting-edge syntheses of natural products and pharmaceuticals using nickel-catalyzed aromatic C-H functionalization are presented.

引用

页数：33

共 115 条

[1] Nickel-Catalyzed Reaction of C-H Bonds in Amides with I2: ortho-Iodination via the Cleavage of C(sp2)-H Bonds and Oxidative Cyclization to β-Lactams via the Cleavage of C(sp3)-H Bonds [J].