Identification of the nukacin KQU-131, a new type-A(II) lantibiotic produced by Staphylococcus hominis KQU-131 isolated from Thai fermented fish product (Pla-ra)

被引:33
作者
Wilaipun, Pongtep [2 ]
Zendo, Takeshi [1 ]
Okuda, Ken-ichi [1 ]
Nakayama, Jiro [1 ]
Sonomoto, Kenji [1 ,3 ]
机构
[1] Kyushu Univ, Lab Microbial Technol, Div Microbial Sci & Technol, Dept Biosci & Biotechnol,Fac Agr,Grad Sch,Higashi, Fukuoka 8128581, Japan
[2] Kasetsart Univ, Dept Fishery Prod, Fac Fisheries, Bangkok 10900, Thailand
[3] Kyushu Univ, Lab Funct Food Design, Dept Funct Metab Design, Bioarchitecture Ctr,Higashi Ku, Fukuoka 8128581, Japan
关键词
lantibiotic; bacteriocin; nukacin KQU-131; nukacin ISK-1; Staphylococcus;
D O I
10.1271/bbb.80239
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Staphylococcus hominis KQU-131, isolated from Thai fermented marine fish, produces a heat stable bacteriocin. Structural and genetic analysis indicated that the bacteriocin is a variant of nukacin ISK-1, a type-A(II) lantibiotic, and we termed the bacteriocin nukacin KQU-131. There were three different amino acid residues between nukacin ISK-1 and nukacin KQU-131, one residue in the leader peptide and the other two in the mature peptide.
引用
收藏
页码:2232 / 2235
页数:4
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