High Ferritin in a Critically ill COVID-19 Patient: The Calm before Cytokine Storm

被引:0
作者
Saki, Safa [1 ]
Mawih, Mustafa Salam [2 ]
机构
[1] Dubai Med Coll Girls, Dept Med, Dubai, U Arab Emirates
[2] St Elizabeth Ft Thomas, Dept Nephrol, Ft Thomas, KY USA
关键词
Cytokine release syndrome; Haemophagocytic lymphohistiocytosis; Macrophage activation syndrome; DIAGNOSIS;
D O I
10.7860/JCDR/2020/44846.13829
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Corona Virus Disease of 2019 (COVID-19) is spreading throughout the world and the United States with confirmed cases in all 50 states. Cytokine Release Syndrome (CRS), or cytokine storm, is being increasingly reported with severe cases of COVID-19 patients and is a common cause of death in these patients. Hereby, authors report a case of critically ill COVID-19 patient who developed cytokine storm. She had a remarkable increase in inflammatory markers and went into multiorgan failure and death in less than 48 hours. Among inflammatory markers, ferritin has a high sensitivity for CRS. This case report sheds light on the importance of following the level of inflammatory markers (especially ferritin) closely in COVID-19 patients. The goal is to diagnose CRS before the patient goes into a full cytokine storm and multiorgan failure, as it may be too late to react then. Even when the patient is clinically stable, a high ferritin level could be the calm before the storm.
引用
收藏
页码:OD03 / OD05
页数:3
相关论文
共 14 条
  • [1] Highly elevated ferritin levels and the diagnosis of hemophagocytic lymphohistiocytosis
    Allen, Carl E.
    Yu, Xiaoying
    Kozinetz, Claudia A.
    McClain, Kenneth L.
    [J]. PEDIATRIC BLOOD & CANCER, 2008, 50 (06) : 1227 - 1235
  • [2] [Anonymous], 2020, MMWR MORB MORTAL WKL
  • [3] Development and Validation of the HScore, a Score for the Diagnosis of Reactive Hemophagocytic Syndrome
    Fardet, Laurence
    Galicier, Lionel
    Lambotte, Olivier
    Marzac, Christophe
    Aumont, Cedric
    Chahwan, Doumit
    Coppo, Paul
    Hejblum, Gilles
    [J]. ARTHRITIS & RHEUMATOLOGY, 2014, 66 (09) : 2613 - 2620
  • [4] COVID-19 Does Not Lead to a "Typical" Acute Respiratory Distress Syndrome
    Gattinoni, Luciano
    Coppola, Silvia
    Cressoni, Massimo
    Busana, Mattia
    Rossi, Sandra
    Chiumello, Davide
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2020, 201 (10) : 1299 - 1300
  • [5] Macrophage Activation-Like Syndrome: A Distinct Entity Leading to Early Death in Sepsis
    Karakike, Eleni
    Giamarellos-Bourboulis, Evangelos J.
    [J]. FRONTIERS IN IMMUNOLOGY, 2019, 10
  • [6] Determination of an Appropriate Cut-Off Value for Ferritin in the Diagnosis of Hemophagocytic Lymphohistiocytosis
    Lehmberg, Kai
    McClain, Kenneth L.
    Janka, Gritta E.
    Allen, Carl E.
    [J]. PEDIATRIC BLOOD & CANCER, 2014, 61 (11) : 2101 - 2103
  • [7] Magro C., 2020, TRANSL RES
  • [8] COVID-19: consider cytokine storm syndromes and immunosuppression
    Mehta, Puja
    McAuley, Daniel F.
    Brown, Michael
    Sanchez, Emilie
    Tattersall, Rachel S.
    Manson, Jessica J.
    [J]. LANCET, 2020, 395 (10229) : 1033 - 1034
  • [9] Ramos-Casals M, 2019, LANCET
  • [10] Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China
    Ruan, Qiurong
    Yang, Kun
    Wang, Wenxia
    Jiang, Lingyu
    Song, Jianxin
    [J]. INTENSIVE CARE MEDICINE, 2020, 46 (05) : 846 - 848