Synthesis and biological evaluation of 4-(2-(dimethylamino)ethoxy)benzohydrazide derivatives as inhibitors of Entamoeba histolyica

被引：11

作者：

Inam, Afreen ^{[1
]}

Mittal, Sonam ^{[2
]}

Rajala, Maitreyi S. ^{[2
]}

Avecilla, Fernando ^{[3
]}

Azam, Amir ^{[1
]}

机构：

[1] Jamia Millia Islamia, Dept Chem, New Delhi 110025, India

[2] Jawaharlal Nehru Univ, Sch Biotechnol, New Delhi 110067, India

[3] Univ A Coruna, Dept Quim Fundamental, Campus Zapateira, La Coruna 15071, Spain

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2016年 / 124卷

关键词：

Hydrazones; Antiamoebic activity; Cytotoxicity; MTT assay; X-ray crystallography; ANTIAMEBIC ACTIVITY; DESIGN; ANTITUMOR;

D O I：

10.1016/j.ejmech.2016.08.022

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In the quest for potent antiamoebic agents, a series of hydrazone hybrids (H1-H30) have been designed and sequentially synthesized. The dimethylaminoethoxy and hydrazone entities incorporated into one molecule proved to be more persuasive and selective approach towards designing of antiamoebic agent. The synthesized compounds exhibited promising results against E. histolytica. The compound N'-(2-chlorobenzylidene)-4-(2-(dimethylamino) ethoxy)benzohydrazide was most impending among the series. Cytotoxicity profile showed better cell viability on lung cancer cell line (A549 cells) by MTT assay. (C) 2016 Published by Elsevier Masson SAS.

引用

页码：445 / 455

页数：11

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