Vascularization in tissue engineering

被引：966

作者：

Rouwkema, Jeroen ^{[1
,2
]}

Rivron, Nicolas C. ^{[1
]}

van Blitterswijk, Clemens A. ^{[1
]}

机构：

[1] Univ Twente, Dept Tissue Regenerat, NL-7522 NB Enschede, Netherlands

[2] Univ Twente, Dept Biomech Engn, NL-7522NB Enschede, Netherlands

来源：

TRENDS IN BIOTECHNOLOGY | 2008年 / 26卷 / 08期

关键词：

D O I：

10.1016/j.tibtech.2008.04.009

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Tissue engineering has been an active field of research for several decades now. However,the amount of clinical applications in the field of tissue engineering is still limited. One of the current limitations of tissue engineering is its inability to provide sufficient blood supply in the initial phase after implantation. Insufficient vascularization can lead to improper cell integration or cell death in tissue-engineered constructs. This review will discuss the advantages and limitations of recent strategies aimed at enhancing the vascularization of tissue-engineered constructs. We will illustrate that combining the efforts of different research lines might be necessary to obtain optimal results in the field.

引用

页码：434 / 441

页数：8

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