BRAF Mutations Occur Infrequently in Ovarian Cancer but Suggest Responsiveness to BRAF and MEK Inhibition

被引:11
作者
Campos, Maira P. [1 ,2 ]
Cohen, Melissa [1 ]
Von Euw, Erika [2 ]
Velculescu, Victor [4 ]
Kujak, Jennifer L. [3 ]
Conklin, Dylan [2 ]
Hallberg, Dorothy [4 ]
Slamon, Dennis J. [1 ,2 ]
Elvin, Julia [5 ]
Konecny, Gottfried E. [1 ,2 ]
机构
[1] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Translat Oncol Res Lab, Santa Monica, CA 90404 USA
[3] Rolling Oaks Radiol, Thousand Oaks, CA USA
[4] Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD USA
[5] Fdn Med, Cambridge, MA USA
关键词
PRECISION MEDICINE; VEMURAFENIB;
D O I
10.1200/PO.18.00025
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
[No abstract available]
引用
收藏
页码:1 / 6
页数:6
相关论文
共 14 条
[1]   AACR Project GENIE: Powering Precision Medicine through an International Consortium [J].
Andre, Fabrice ;
Arnedos, Monica ;
Baras, Alexander S. ;
Baselga, Jose ;
Bedard, Philippe L. ;
Berger, Michael F. ;
Bierkens, Mariska ;
Calvo, Fabien ;
Cerami, Ethan ;
Chakravarty, Debyani ;
Dang, Kristen K. ;
Davidson, Nancy E. ;
Del Vecchio, Fitz Catherine ;
Dogan, Semih ;
DuBois, Raymond N. ;
Ducar, Matthew D. ;
Futreal, P. Andrew ;
Gao Jianjiong ;
Garcia, Francisco ;
Gardos, Stu ;
Gocke, Christopher D. ;
Gross, Benjamin E. ;
Guinney, Justin ;
Heins, Zachary J. ;
Hintzen, Stephanie ;
Horlings, Hugo ;
Hudecek, Jan ;
Hyman, David M. ;
Kamel-Reid, Suzanne ;
Kandoth, Cyriac ;
Kinyua, Walter ;
Kumari, Priti ;
Kundra, Ritika ;
Ladanyi, Marc ;
Lefebvre, Celine ;
LeNoue-Newton, Michele L. ;
Lepisto, Eva M. ;
Levy, Mia A. ;
Lindeman, Neal, I ;
Lindsay, James ;
Liu, David ;
Lu Zhibin ;
MacConaill, Laura E. ;
Ian, Maurer ;
Maxwell, David S. ;
Meijer, Gerrit A. ;
Meric-Bernstam, Funda ;
Micheel, Christine M. ;
Miller, Clinton ;
Mills, Gordon .
CANCER DISCOVERY, 2017, 7 (08) :818-831
[2]   The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website [J].
Bamford, S ;
Dawson, E ;
Forbes, S ;
Clements, J ;
Pettett, R ;
Dogan, A ;
Flanagan, A ;
Teague, J ;
Futreal, PA ;
Stratton, MR ;
Wooster, R .
BRITISH JOURNAL OF CANCER, 2004, 91 (02) :355-358
[3]   The NCl-MATCH trial and precision medicine in gynecologic cancers [J].
Barroilhet, Lisa ;
Matulonis, Ursula .
GYNECOLOGIC ONCOLOGY, 2018, 148 (03) :585-590
[4]   Integrated genomic analyses of ovarian carcinoma [J].
Bell, D. ;
Berchuck, A. ;
Birrer, M. ;
Chien, J. ;
Cramer, D. W. ;
Dao, F. ;
Dhir, R. ;
DiSaia, P. ;
Gabra, H. ;
Glenn, P. ;
Godwin, A. K. ;
Gross, J. ;
Hartmann, L. ;
Huang, M. ;
Huntsman, D. G. ;
Iacocca, M. ;
Imielinski, M. ;
Kalloger, S. ;
Karlan, B. Y. ;
Levine, D. A. ;
Mills, G. B. ;
Morrison, C. ;
Mutch, D. ;
Olvera, N. ;
Orsulic, S. ;
Park, K. ;
Petrelli, N. ;
Rabeno, B. ;
Rader, J. S. ;
Sikic, B. I. ;
Smith-McCune, K. ;
Sood, A. K. ;
Bowtell, D. ;
Penny, R. ;
Testa, J. R. ;
Chang, K. ;
Dinh, H. H. ;
Drummond, J. A. ;
Fowler, G. ;
Gunaratne, P. ;
Hawes, A. C. ;
Kovar, C. L. ;
Lewis, L. R. ;
Morgan, M. B. ;
Newsham, I. F. ;
Santibanez, J. ;
Reid, J. G. ;
Trevino, L. R. ;
Wu, Y. -Q. ;
Wang, M. .
NATURE, 2011, 474 (7353) :609-615
[5]   BRAFV600E: Implications for Carcinogenesis and Molecular Therapy [J].
Cantwell-Dorris, Emma R. ;
O'Leary, John J. ;
Sheils, Orla M. .
MOLECULAR CANCER THERAPEUTICS, 2011, 10 (03) :385-394
[6]   Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation [J].
Chapman, Paul B. ;
Hauschild, Axel ;
Robert, Caroline ;
Haanen, John B. ;
Ascierto, Paolo ;
Larkin, James ;
Dummer, Reinhard ;
Garbe, Claus ;
Testori, Alessandro ;
Maio, Michele ;
Hogg, David ;
Lorigan, Paul ;
Lebbe, Celeste ;
Jouary, Thomas ;
Schadendorf, Dirk ;
Ribas, Antoni ;
O'Day, Steven J. ;
Sosman, Jeffrey A. ;
Kirkwood, John M. ;
Eggermont, Alexander M. M. ;
Dreno, Brigitte ;
Nolop, Keith ;
Li, Jiang ;
Nelson, Betty ;
Hou, Jeannie ;
Lee, Richard J. ;
Flaherty, Keith T. ;
McArthur, Grant A. .
NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (26) :2507-2516
[7]   Evaluating cell lines as tumour models by comparison of genomic profiles [J].
Domcke, Silvia ;
Sinha, Rileen ;
Levine, Douglas A. ;
Sander, Chris ;
Schultz, Nikolaus .
NATURE COMMUNICATIONS, 2013, 4
[8]   Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing [J].
Frampton, Garrett M. ;
Fichtenholtz, Alex ;
Otto, Geoff A. ;
Wang, Kai ;
Downing, Sean R. ;
He, Jie ;
Schnall-Levin, Michael ;
White, Jared ;
Sanford, Eric M. ;
An, Peter ;
Sun, James ;
Juhn, Frank ;
Brennan, Kristina ;
Iwanik, Kiel ;
Maillet, Ashley ;
Buell, Jamie ;
White, Emily ;
Zhao, Mandy ;
Balasubramanian, Sohail ;
Terzic, Selmira ;
Richards, Tina ;
Banning, Vera ;
Garcia, Lazaro ;
Mahoney, Kristen ;
Zwirko, Zac ;
Donahue, Amy ;
Beltran, Himisha ;
Mosquera, Juan Miguel ;
Rubin, Mark A. ;
Dogan, Snjezana ;
Hedvat, Cyrus V. ;
Berger, Michael F. ;
Pusztai, Lajos ;
Lechner, Matthias ;
Boshoff, Chris ;
Jarosz, Mirna ;
Vietz, Christine ;
Parker, Alex ;
Miller, Vincent A. ;
Ross, Jeffrey S. ;
Curran, John ;
Cronin, Maureen T. ;
Stephens, Philip J. ;
Lipson, Doron ;
Yelensky, Roman .
NATURE BIOTECHNOLOGY, 2013, 31 (11) :1023-+
[9]   Therapeutic Potential of the Poly(ADP-ribose) Polymerase Inhibitor Rucaparib for the Treatment of Sporadic Human Ovarian Cancer [J].
Ihnen, Maike ;
Eulenburg, Christine Zu ;
Kolarova, Teodora ;
Qi, Jing Wei ;
Manivong, Kanthinh ;
Chalukya, Meenal ;
Dering, Judy ;
Anderson, Lee ;
Ginther, Charles ;
Meuter, Alexandra ;
Winterhoff, Boris ;
Jones, Sian ;
Velculescu, Victor E. ;
Venkatesan, Natarajan ;
Rong, Hong-Mei ;
Dandekar, Sugandha ;
Udar, Nitin ;
Jaenicke, Fritz ;
Los, Gerrit ;
Slamon, Dennis J. ;
Konecny, Gottfried E. .
MOLECULAR CANCER THERAPEUTICS, 2013, 12 (06) :1002-1015
[10]   Combined Vemurafenib and Cobimetinib in BRAF-Mutated Melanoma [J].
Larkin, James ;
Ascierto, Paolo A. ;
Dreno, Brigitte ;
Atkinson, Victoria ;
Liszkay, Gabriella ;
Maio, Michele ;
Mandala, Mario ;
Demidov, Lev ;
Stroyakovskiy, Daniil ;
Thomas, Luc ;
de la Cruz-Merino, Luis ;
Dutriaux, Caroline ;
Garbe, Claus ;
Sovak, Mika A. ;
Chang, Ilsung ;
Choong, Nicholas ;
Hack, Stephen P. ;
McArthur, Grant A. ;
Ribas, Antoni .
NEW ENGLAND JOURNAL OF MEDICINE, 2014, 371 (20) :1867-1876