Gene-delivery systems using cationic polymers

被引：1

作者：

Garnett, MC ^{[1
]}

机构：

[1] Univ Nottingham, Sch Pharmaceut Chem, Nottingham NG7 2RD, England

来源：

CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS | 1999年 / 16卷 / 02期

关键词：

gene therapy; cationic polymers; polyelectrolytes; nonviral vectors; receptor targeting;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Gene therapy will benefit a range of diseases from single-gene defects, to chronic diseases such as cancer, to vaccination. Initially gene therapy used viral vectors, but the advantages of nonviral systems are now being fully appreciated. This review focuses on cationic polymers as a delivery system for DNA. The physicochemical characterization of DNA polycation complexes that condense and protect DNA from nuclease digestion are considered, together with further factors such as ligand targeting, endosomal escape, and nuclear localization. Where possible, the relative efficacy of different cationic polymer delivery systems is compared.

引用

页码：147 / 207

页数：61

共 185 条

[11] Regulation of in vitro gene expression using antisense oligonucleotides or antisense expression plasmids transfected using starburst PAMAM dendrimers [J].

Bielinska, A ;

KukowskaLatallo, JF ;

Johnson, J ;

Tomalia, DA ;

Baker, JR .

NUCLEIC ACIDS RESEARCH, 1996, 24 (11) :2176-2182

[12]

BOMMINENI VR, 1994, J BIOL CHEM, V269, P25200

[13] POLY-L-ORNITHINE-MEDIATED TRANSFORMATION OF MAMMALIAN-CELLS [J].

BOND, VC ;

WOLD, B .

MOLECULAR AND CELLULAR BIOLOGY, 1987, 7 (06) :2286-2293

[14] A VERSATILE VECTOR FOR GENE AND OLIGONUCLEOTIDE TRANSFER INTO CELLS IN CULTURE AND IN-VIVO - POLYETHYLENIMINE [J].

BOUSSIF, O ;

LEZOUALCH, F ;

ZANTA, MA ;

MERGNY, MD ;

SCHERMAN, D ;

DEMENEIX, B ;

BEHR, JP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (16) :7297-7301

[15]

Boussif O, 1996, GENE THER, V3, P1074

[16] THE ASSOCIATION OF POLYPEPTIDE HORMONES AND GROWTH-FACTORS WITH THE NUCLEI OF TARGET-CELLS [J].

BURWEN, SJ ;

JONES, AL .

TRENDS IN BIOCHEMICAL SCIENCES, 1987, 12 (04) :159-162

[17] RECEPTOR-MEDIATED GENE-TRANSFER INTO HUMAN T-LYMPHOCYTES VIA BINDING OF DNA/CD3 ANTIBODY PARTICLES TO THE CD3 T-CELL RECEPTOR COMPLEX [J].

BUSCHLE, M ;

COTTEN, M ;

KIRLAPPOS, H ;

MECHTLER, K ;

SCHAFFNER, G ;

ZAUNER, W ;

BIRNSTIEL, ML ;

WAGNER, E .

HUMAN GENE THERAPY, 1995, 6 (06) :753-761

[18] CONFORMATIONAL STUDIES OF NUCLEOPROTEIN - CIRCULAR-DICHROISM OF DEOXYRIBONUCLEIC ACID BASE PAIRS BOUND BY POLYLYSINE [J].

CHANG, C ;

WEISKOPF, M ;

LI, HJ .

BIOCHEMISTRY, 1973, 12 (16) :3028-3032

[19] DNA CONDENSATION WITH POLYAMINES .2. ELECTRON-MICROSCOPIC STUDIES [J].

CHATTORAJ, DK ;

GOSULE, LC ;

SCHELLMAN, JA .

JOURNAL OF MOLECULAR BIOLOGY, 1978, 121 (03) :327-337

[20] GALACTOSYLATED HISTONE-MEDIATED GENE-TRANSFER AND EXPRESSION [J].

CHEN, J ;

STICKLES, RJ ;

DAICHENDT, KA .

HUMAN GENE THERAPY, 1994, 5 (04) :429-435

← 1 2 3 4 5 6 7 8 9 10 →