The overexpression and predictive significance of MMP-12 in esophageal squamous cell carcinoma

被引：32

作者：

Han, Fei ^{[1
,2
]}

Zhang, Suxia ^{[2
]}

Zhang, Long ^{[2
]}

Hao, Qiongyu ^{[3
]}

机构：

[1] Washington Univ, Sch Med, Div Radiol Sci, St Louis, MO 63110 USA

[2] Tongji Univ, Sch Med, Tongji Hosp, Dept Pathol, Shanghai 200065, Peoples R China

[3] NYU, Dept Cell Biol, Sch Med, New York, NY 10016 USA

来源：

PATHOLOGY RESEARCH AND PRACTICE | 2017年 / 213卷 / 12期

基金：

中国国家自然科学基金;

关键词：

MMP-12; ESCC; Metastasis; Prognosis; MACROPHAGE METALLOELASTASE GENE; MATRIX METALLOPROTEINASES; CLINICOPATHOLOGICAL SIGNIFICANCE; POOR-PROGNOSIS; LUNG-CARCINOMA; TUMOR-CELLS; EXPRESSION; CANCER; INVASION; METASTASIS;

D O I：

10.1016/j.prp.2017.09.023

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Matrix metalloproteinase (MMP)-mediated degradation of the extracellular matrix is a major factor for tumor invasion and metastasis. MMP-12, as metalloelastase, its function in tumor progression remains contradictory. This study was undertaken to investigate the role of MMP-12 in esophageal squamous cell carcinoma (ESCC). We analyzed the protein expression of MMP-12 and its association with clinicopatholigical parameters, as well as survival analysis. MMP-12 was highly expressed in tumor cells comparing with normal epithelial cells. The high expression of MMP-12 was significantly correlated with tumor grade and stage, nodal metastasis and poor survival of ESCC. Cox multivariate analysis revealed that MMP-12 was an independent prognostic factor in ESCC. Our results suggest that MMP-12 might act as a potential target for the development of novel therapeutics of esophageal squamous cell carcinoma.

引用

页码：1519 / 1522

页数：4

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