Dendritic morphology of amygdala and hippocampal neurons in more and less predator stress responsive rats and more and less spontaneously anxious handled controls

被引:54
作者
Adamec, Robert [1 ]
Hebert, Mark [1 ]
Blundell, Jacqueline [1 ]
Mervis, Ronald F. [2 ,3 ]
机构
[1] Mem Univ Newfoundland, Dept Psychol, St John, NF A1B 3X9, Canada
[2] Univ S Florida, Coll Med, Dept Neurosurg & Brain Repair, Ctr Excellence Aging & Brain Repair, Tampa, FL 33612 USA
[3] Neurostruct Res Labs Inc, Tampa, FL 33637 USA
关键词
Stress; Amygdala; Hippocampus; Morphology; Resilience; Vulnerability; ANXIETY-LIKE BEHAVIOR; NATIONAL COMORBIDITY SURVEY; BASOLATERAL AMYGDALA; NEURAL PLASTICITY; ANIMAL-MODELS; PREFRONTAL CORTEX; TRAUMATIC STRESS; NMDA RECEPTORS; RODENT ANXIETY; HOLE-BOARD;
D O I
10.1016/j.bbr.2011.09.009
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
We investigated the neurobiological bases of variation in response to predator stress (PS). Sixteen days after treatment (PS or handling), rats were grouped according to anxiety in the elevated plus maze (EPM). Acoustic startle was also measured. We examined the structure of dendritic trees of basolateral amygdala (BLA) output neurons (stellate and pyramidal cells) and of dorsal hippocampal (DHC) dentate granule cells of less anxious (LA) and more (extremely) anxious (MA) stressed animals (PSLA and PSMA). Handled controls (HC) which were less anxious (HCLA) and spontaneously more anxious (HCMA) equivalently to predator stressed subgroups were also studied. Golgi analysis revealed BLA output neurons of HCMA rats exhibited longer, more branched dendrites with higher spine density than the other groups of rats, which did not differ. Finally, spine density of DHC granule cells was equally depressed in HCMA and PSMA rats relative to HCLA and PSLA rats. Total dendritic length of BLA pyramidal and stellate cells (positive predictor) and DHC spine density (negative predictor) together accounted for 96% of the variance of anxiety of handled rats. DHC spine density was a negative predictor of PSMA and PSLA anxiety, accounting for 70% of the variance. Data are discussed in the context of morphological differences as phenotypic markers of a genetic predisposition to anxiety in handled controls, and a possible genetic vulnerability to predator stress expressed as reduced spine density in the DHC. Significance of findings for animal models of anxiety and hyperarousal comorbidities of PTSD are discussed. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码:133 / 146
页数:14
相关论文
共 63 条
[1]   Neural plasticity, neuropeptides and anxiety in animals - implications for understanding and treating affective disorder following traumatic stress in humans [J].
Adamec, R ;
Kent, P ;
Anisman, H ;
Shallow, T ;
Merali, Z .
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 1998, 23 (02) :301-318
[2]  
Adamec R, 2006, PTSD: BRAIN MECHANISMS AND CLINICAL IMPLICATIONS, P61, DOI 10.1007/4-431-29567-4_7
[3]   Does long term potentiation in periacqueductal gray (PAG) mediate lasting changes in rodent anxiety-like behavior (ALB) produced by predator stress? - Effects of low frequency stimulation (LFS) of PAC on place preference and changes in ALE produced by predator stress [J].
Adamec, R .
BEHAVIOURAL BRAIN RESEARCH, 2001, 120 (02) :111-135
[4]   Role of NMDA receptors in the lateralized potentiation of amygdala afferent and efferent neural transmission produced by predator stress [J].
Adamec, R ;
Blundell, J ;
Burton, P .
PHYSIOLOGY & BEHAVIOR, 2005, 86 (1-2) :75-91
[6]   Long-lasting, selective, anxiogenic effects of feline predator stress in mice [J].
Adamec, R ;
Walling, S ;
Burton, P .
PHYSIOLOGY & BEHAVIOR, 2004, 83 (03) :401-410
[7]  
Adamec RE, 1999, PHYSIOL BEHAV, V65, P739
[8]   Relationship of the predatory attack experience to neural plasticity, pCREB expression and neuroendocrine response [J].
Adamec, RE ;
Blundell, J ;
Burton, P .
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2006, 30 (03) :356-375
[9]   Neural circuit changes mediating lasting brain and behavioral response to predator stress [J].
Adamec, RE ;
Blundell, J ;
Burton, P .
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2005, 29 (08) :1225-1241
[10]   LASTING EFFECTS ON RODENT ANXIETY OF A SINGLE EXPOSURE TO A CAT [J].
ADAMEC, RE ;
SHALLOW, T .
PHYSIOLOGY & BEHAVIOR, 1993, 54 (01) :101-109