Origins, genetic landscape, and emerging therapies of small cell lung cancer

被引：193

作者：

Semenova, Ekaterina A. ^{[1
]}

Nagel, Remco ^{[1
]}

Berns, Anton ^{[1
]}

机构：

[1] Netherlands Canc Inst, Div Mol Genet, NL-1066 CX Amsterdam, Netherlands

来源：

GENES & DEVELOPMENT | 2015年 / 29卷 / 14期

基金：

欧洲研究理事会;

关键词：

SCLC; cell of origin; neuroendocrine; driver; GEMM; targeted therapy; FAMILY DNA AMPLIFICATION; RANDOMIZED PHASE-II; RETINOBLASTOMA PROTEIN; STEM-CELLS; NEUROENDOCRINE DIFFERENTIATION; INTERNATIONAL-ASSOCIATION; BRONCHIAL EPITHELIUM; PROGENITOR CELLS; MESSENGER-RNA; MOUSE MODELS;

D O I：

10.1101/gad.263145.115

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Lung cancer is the leading cause of cancer deaths, with small cell lung cancer (SCLC) representing the most aggressive subtype. Standard treatments have not changed in decades, and the 5-year survival rate has remained <7%. Genomic analyses have identified key driver mutations of SCLC that were subsequently validated in animal models of SCLC. To provide better treatment options, a deeper understanding of the cellular and molecular mechanisms underlying SCLC initiation, progression, metastasis, and acquisition of resistance is required. In this review, we describe the genetic landscape of SCLC, features of the cell of origin, and targeted therapeutic approaches.

引用

页码：1447 / 1462

页数：16

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