The negative predictive value of breast Magnetic Resonance Imaging in noncalcified BIRADS 3 lesions

被引：24
作者：
Dorrius, M. D. [1 ]
Pijnappel, R. M. [1 ]
Sijens, P. E. [1 ]
van der Weide, M. C. Jansen [1 ]
Oudkerk, M. [1 ]
机构：
[1] Univ Groningen, Univ Med Ctr Groningen, Dept Radiol, NL-9700 RB Groningen, Netherlands
来源：
EUROPEAN JOURNAL OF RADIOLOGY | 2012年 / 81卷 / 02期
关键词：
Breast cancer; Mammography; MRI; BI-RADS; Probably benign lesions; MR; MAMMOGRAPHY; ACCURACY; WOMEN; AGE;
D O I：
10.1016/j.ejrad.2010.12.046
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Purpose: The purpose of this study is to determine whether breast MRI can provide a sufficient NPV to safely rule out malignancy in mammographic BIRADS 3 lesions. Materials and methods: In a 3-year consecutive mammographic examination study 176 out of 4391 patients had a lesion classified as BIRADS 3. 76 out of 176 patients underwent breast MRI as diagnostic work-up. Lesions which MRI classified as BIRADS 1 or 2 were considered negative for malignancy. Sensitivity, specificity, PPV and NPV were calculated. Results: In 27 out of 76 (35.5%) patients MRI showed no enhancement and was classified as BIRADS 1. In 25 (32.9%) patients MRI showed focal or mass enhancement classified as BIRADS 2. In these 52 (68.4%) patients no malignancy was found during at least 2 years study follow-up. The other 24 (31.6%) patients had a lesion classified as BIRADS >= 3. Thirteen of these 24 lesions were malignant by pathology. MRI had a sensitivity of 100% (95% CI: 75-100%), specificity of 82.5% (95% CI: 71-91%), PPV of 54.2% (95% CI: 33-74%) and NPV of 100% (95% CI: 93-100%). Conclusion: Breast MRI should be used in a diagnostic strategy for the work-up of noncalcified BIRADS 3 lesions. Malignancy is ruled out with a very high level of confidence in the majority of patients (68%), herewith avoiding invasive diagnostic procedures. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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收藏
页码：209 / 213
页数：5
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