Atopic Dermatitis and the Nervous System

被引：34
作者：
Misery, Laurent [1 ,2 ,3 ]
机构：
[1] Univ Brest, Brest, France
[2] Univ Hosp, Dept Dermatol, F-29609 Brest, France
[3] Univ Hosp, Lab Skin Neurobiol, F-29609 Brest, France
来源：
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY | 2011年 / 41卷 / 03期
关键词：
Atopic dermatitis; Skin; Nerve; Neuropeptide; Neurotransmitter; Inflammation; GENE-RELATED PEPTIDE; BLOOD MONONUCLEAR-CELLS; IMMUNO-CUTANEOUS SYSTEM; GROWTH-FACTOR NGF; LANGERHANS CELLS; SUBSTANCE-P; SKIN-LESIONS; BETA-2-ADRENERGIC RECEPTOR; ULTRAVIOLET-RADIATION; EPIDERMAL-CELLS;
D O I：
10.1007/s12016-010-8225-z
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Due to the narrow associations between the skin, immune system, and nervous system, nerve endings are very important in the pathophysiology of inflammatory dermatoses and especially in atopic dermatitis. Many neurotransmitters and nerve growth factors that are released in blood or skin are involved in neurogenic inflammation, which dramatically enhance the inflammation induced by immune cells. During times of stress, their release is highly enhanced. In atopic dermatitis lesions, there are many specific changes in skin neurobiology and neurophysiology. These interesting data suggest that novel therapeutic possibilities can be imagined.
引用
收藏
页码：259 / 266
页数：8
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