Neurotrophin receptors in taste buds of adult zebrafish (Danio rerio)

被引：36
作者：
Germana, A
González-Martínez, T
Catania, S
Laura, R
Cobo, J
Ciriaco, E
Vega, JA
机构：
[1] Univ Oviedo, Fac Med, Dept Morfol & Biol Celular, E-33006 Oviedo, Spain
[2] Univ Messina, Dipartimento Morfol Biochim Fisiol & Prod Anim, I-98100 Messina, Italy
[3] Univ Oviedo, Fac Med, Dept Cirugia & Especialidades Med Quirurg Estomat, E-33006 Oviedo, Spain
[4] Univ Oviedo, Fac Med, Inst Oncol Principado Asturias, E-33006 Oviedo, Spain
来源：
NEUROSCIENCE LETTERS | 2004年 / 354卷 / 03期
关键词：
taste buds; neurotrophins; Trk neurotrophin receptors; zebrafish;
D O I：
10.1016/j.neulet.2003.10.017
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
TrkB plays crucial roles in the development and maintenance of taste buds in mammals. In this study we investigated the presence and cell localization of Trks (TrkA, TrkB and TrkC) in taste buds of the zebrafish (Danio rerio) using Western blot and immunohistochemistry. Proteins of 140 and 145 kDa, identified as full-length TrkA and TrkB, were detected. Conversely, the anti-TrkC antibody recognized a protein lower than expected (100 kDa). In agreement with these results the sensory cells of taste buds, displayed TrkA- and TrkB-like, but not TrkC-like, immunoreactivity. TrkA and TrkB co-existed in the same taste buds, but remains to be clarified whether or not they are co-expressed in the same cells. Present results demonstrate that as for mammals neurotrophins might play a role in sensory cells of the teleostean taste buds. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
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页码：189 / 192
页数：4
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