Anti-influenza Virus Polyketides from the Acid-Tolerant Fungus Penicillium purpurogenum JS']JS03-21

被引：69

作者：

Wang, Hui ^{[1
]}

Wang, Yi ^{[1
]}

Wang, Wei ^{[1
]}

Fu, Peng ^{[1
]}

Liu, Peipei ^{[1
]}

Zhu, Weiming ^{[1
]}

机构：

[1] Ocean Univ China, Key Lab Marine Drugs, Chinese Minist Educ, Sch Med & Pharm, Qingdao 266003, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2011年 / 74卷 / 09期

基金：

中国国家自然科学基金;

关键词：

ENDOPHYTIC FUNGUS; PH REGULATION; METABOLITES; AZAPHILONE; INHIBITOR;

D O I：

10.1021/np2004769

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Fractionation of the ethyl acetate extract of an acid-tolerant fungus, Penicillium purpurogenum JS03-21, resulted in the isolation of six new compounds, purpurquinones A-C (1-3), purpuresters A and B (4 and 5), and 2,6,7-trihydroxy-3-methylnaphthalene-1,4-dione (6), together with three known compounds, TAN-931 (7), (-)-mitorubrin (8), and orsellinic acid. The structures of 1-6 were elucidated primarily by NMR experiments. The absolute configurations of 1-4 were assigned on the basis of CD and NOESY data. Compounds 2-4 and 7 exhibited significant antiviral activity against H1N1, with IC(50) values of 61.3, 64.0, 85.3, and 58.6 mu M, respectively.

引用

页码：2014 / 2018

页数：5

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