Anti-influenza Virus Polyketides from the Acid-Tolerant Fungus Penicillium purpurogenum JS']JS03-21

被引：67

作者：

Wang, Hui ^{[1
]}

Wang, Yi ^{[1
]}

Wang, Wei ^{[1
]}

Fu, Peng ^{[1
]}

Liu, Peipei ^{[1
]}

Zhu, Weiming ^{[1
]}

机构：

[1] Ocean Univ China, Key Lab Marine Drugs, Chinese Minist Educ, Sch Med & Pharm, Qingdao 266003, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2011年 / 74卷 / 09期

基金：

中国国家自然科学基金;

关键词：

ENDOPHYTIC FUNGUS; PH REGULATION; METABOLITES; AZAPHILONE; INHIBITOR;

D O I：

10.1021/np2004769

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Fractionation of the ethyl acetate extract of an acid-tolerant fungus, Penicillium purpurogenum JS03-21, resulted in the isolation of six new compounds, purpurquinones A-C (1-3), purpuresters A and B (4 and 5), and 2,6,7-trihydroxy-3-methylnaphthalene-1,4-dione (6), together with three known compounds, TAN-931 (7), (-)-mitorubrin (8), and orsellinic acid. The structures of 1-6 were elucidated primarily by NMR experiments. The absolute configurations of 1-4 were assigned on the basis of CD and NOESY data. Compounds 2-4 and 7 exhibited significant antiviral activity against H1N1, with IC(50) values of 61.3, 64.0, 85.3, and 58.6 mu M, respectively.

引用

页码：2014 / 2018

页数：5

共 19 条

[1] Radical-Scavenging Activity of Orsellinates [J].

Barros Lopes, Thiago Inacio ;

Gomes Coelho, Roberta ;

Cristiane Yoshida, Nidia ;

Kika Honda, Neli .

CHEMICAL & PHARMACEUTICAL BULLETIN, 2008, 56 (11) :1551-1554

[2] Microbial and enzymatic transformations of flavonoids [J].

Das, S ;

Rosazza, JPN .

JOURNAL OF NATURAL PRODUCTS, 2006, 69 (03) :499-508

[3] Antifungal metabolites from the plant endophytic fungus Pestalotiopsis foedan [J].

Ding, Gang ;

Liu, Shuchun ;

Guo, Liangdong ;

Zhou, Yuguang ;

Che, Yongsheng .

JOURNAL OF NATURAL PRODUCTS, 2008, 71 (04) :615-618

[4] PH REGULATION IS A MAJOR DETERMINANT IN EXPRESSION OF A FUNGAL PENICILLIN BIOSYNTHETIC GENE [J].

ESPESO, EA ;

TILBURN, J ;

ARST, HN ;

PENALVA, MA .

EMBO JOURNAL, 1993, 12 (10) :3947-3956

[5] Iota-Carrageenan is a potent inhibitor of rhinovirus infection [J].

Grassauer, Andreas ;

Weinmuellner, Regina ;

Meier, Christiane ;

Pretsch, Alexander ;

Prieschl-Grassauer, Eva ;

Unger, Hermann .

VIROLOGY JOURNAL, 2008, 5 (1)

[6] New Insights into the Signaling Mechanism of the pH-responsive, Membrane-integrated Transcriptional Activator CadC of Escherichia coli [J].

Haneburger, Ina ;

Eichinger, Andreas ;

Skerra, Arne ;

Jung, Kirsten .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (12) :10681-10689

[7] Aurintricarboxylic acid inhibits influenza virus neuraminidase [J].

Hung, Hui-Chen ;

Tseng, Ching-Ping ;

Yang, Jinn-Moon ;

Ju, Yi-Wei ;

Tseng, Sung-Nain ;

Chen, Yen-Fu ;

Chao, Yu-Sheng ;

Hsieh, Hsing-Pang ;

Shih, Shin-Ru ;

Hsu, John T. -A. .

ANTIVIRAL RESEARCH, 2009, 81 (02) :123-131

[8] TAN-931, A NOVEL NONSTEROIDAL AROMATASE INHIBITOR PRODUCED BY PENICILLIUM-FUNICULOSUM NO 8974 .1. TAXONOMY, FERMENTATION, ISOLATION, CHARACTERIZATION AND BIOLOGICAL-ACTIVITIES [J].

ISHII, T ;

HIDA, T ;

ISHIMARU, T ;

IINUMA, S ;

SUDO, K ;

MUROI, M ;

KANAMARU, T ;

OKAZAKI, H .

JOURNAL OF ANTIBIOTICS, 1991, 44 (06) :589-599

[9] pH regulation of sterigmatocystin and aflatoxin biosynthesis in Aspergillus spp. [J].

Keller, NP ;

Nesbitt, C ;

Sarr, B ;

Phillips, TD ;

Burow, GB .

PHYTOPATHOLOGY, 1997, 87 (06) :643-648

[10] PURPACTINS, NEW INHIBITORS OF ACYL-COA - CHOLESTEROL ACYLTRANSFERASE PRODUCED BY PENICILLIUM-PURPUROGENUM .2. STRUCTURE ELUCIDATION OF PURPACTIN-A, PURPACTIN-B AND PURPACTIN-C [J].

NISHIDA, H ;

TOMODA, H ;

CAO, J ;

OKUDA, S ;

OMURA, S .

JOURNAL OF ANTIBIOTICS, 1991, 44 (02) :144-157

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