Microbiota in digestive cancers: our new partner?

被引：10

作者：

Lopez, Anthony ^{[1
,2
]}

Hansmannel, Franck ^{[3
]}

Kokten, Tunay ^{[3
]}

Bronowicki, Jean-Pierre ^{[1
,2
]}

Melhem, Hassan ^{[3
]}

Sokol, Harry ^{[4
,5
,6
,7
]}

Peyrin-Biroulet, Laurent ^{[1
,2
]}

机构：

[1] Lorraine Univ, Nancy Univ Hosp, Dept Gastroenterol & Hepatol, Vandoeuvre Les Nancy, France

[2] Lorraine Univ, Nancy Univ Hosp, Inserm U954, Vandoeuvre Les Nancy, France

[3] Lorraine Univ, Inserm U954, Dept Res, Vandoeuvre Les Nancy, France

[4] UPMC Univ Paris 06, Sorbonne Univ, St Antoine Hosp,UMR 7203, Dept Res,Inserm ERL 1157,Avenir Team Gut Microbio, Paris, France

[5] INRA, Dept Res, Micalis UMR1319, Jouy En Josas, France

[6] AgroParisTech, Jouy En Josas, France

[7] UPMC Univ Paris 06, St Antoine Hosp, AP HP, Dept Gastroenterol, Paris, France

来源：

CARCINOGENESIS | 2017年 / 38卷 / 12期

关键词：

ENTEROTOXIGENIC BACTEROIDES-FRAGILIS; POLYMERASE-CHAIN-REACTION; REGULATORY T-CELLS; COLORECTAL-CANCER; ESCHERICHIA-COLI; GASTRIC-CANCER; FUSOBACTERIUM-NUCLEATUM; GUT MICROBIOTA; INTESTINAL INFLAMMATION; TUMOR MICROENVIRONMENT;

D O I：

10.1093/carcin/bgx087

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Evolution led to an essential symbiotic relationship between the host and commensal microbiota, regulating physiological functions including inflammation and immunity. This equilibrium can be disturbed by environmental factors such as lifestyle, diet or antibiotic pressure, contributing to create a dysbiosis. There is much evidence about the gut microbiota's contribution to carcinogenesis, involving pro-inflammatory and immunosuppressive signals. At the same time, it seems to be increasingly clear that commensal microbes can modulate cancer therapy efficacy and safety, in particular, innovating treatments as immune checkpoint inhibitors. In this review, we discuss how the microbiota can promote digestive tract carcinogenesis, responsiveness to cancer therapeutics and cancer-associated complications.

引用

页码：1157 / 1166

页数：10

共 102 条

[1] Molecular detection, quantification, and isolation of Streptococcus gallolyticus bacteria colonizing colorectal tumors: inflammation-driven potential of carcinogenesis via IL-1, COX-2, and IL-8 [J].

Abdulamir, Ahmed S. ;

Hafidh, Rand R. ;

Abu Bakar, Fatimah .

MOLECULAR CANCER, 2010, 9 :249

[2] Vaccination prevents Helicobacter pylori-induced alterations of the gastric flora in mice [J].

Aebischer, T ;

Fischer, A ;

Walduck, A ;

Schlötelburg, C ;

Lindig, M ;

Schreiber, S ;

Meyer, TF ;

Bereswill, S ;

Göbel, UB .

FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, 2006, 46 (02) :221-229

[3] Pathobiology of Helicobacter pylori-Induced Gastric Cancer [J].

Amieva, Manuel ;

Peek, Richard M., Jr. .

GASTROENTEROLOGY, 2016, 150 (01) :64-78

[4] Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation [J].

Arpaia, Nicholas ;

Campbell, Clarissa ;

Fan, Xiying ;

Dikiy, Stanislav ;

van der Veeken, Joris ;

deRoos, Paul ;

Liu, Hui ;

Cross, Justin R. ;

Pfeffer, Klaus ;

Coffer, Paul J. ;

Rudensky, Alexander Y. .

NATURE, 2013, 504 (7480) :451-+

[5] Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota [J].

Arthur, Janelle C. ;

Perez-Chanona, Ernesto ;

Muehlbauer, Marcus ;

Tomkovich, Sarah ;

Uronis, Joshua M. ;

Fan, Ting-Jia ;

Campbell, Barry J. ;

Abujamel, Turki ;

Dogan, Belgin ;

Rogers, Arlin B. ;

Rhodes, Jonathan M. ;

Stintzi, Alain ;

Simpson, Kenneth W. ;

Hansen, Jonathan J. ;

Keku, Temitope O. ;

Fodor, Anthony A. ;

Jobin, Christian .

SCIENCE, 2012, 338 (6103) :120-123

[6] Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species [J].

Atarashi, Koji ;

Tanoue, Takeshi ;

Shima, Tatsuichiro ;

Imaoka, Akemi ;

Kuwahara, Tomomi ;

Momose, Yoshika ;

Cheng, Genhong ;

Yamasaki, Sho ;

Saito, Takashi ;

Ohba, Yusuke ;

Taniguchi, Tadatsugu ;

Takeda, Kiyoshi ;

Hori, Shohei ;

Ivanov, Ivaylo I. ;

Umesaki, Yoshinori ;

Itoh, Kikuji ;

Honda, Kenya .

SCIENCE, 2011, 331 (6015) :337-341

[7] Stomach microbiota composition varies between patients with non-atrophic gastritis and patients with intestinal type of gastric cancer [J].

Aviles-Jimenez, Francisco ;

Vazquez-Jimenez, Flor ;

Medrano-Guzman, Rafael ;

Mantilla, Alejandra ;

Torres, Javier .

SCIENTIFIC REPORTS, 2014, 4

[8] Real-time polymerase chain reaction quantification of specific butyrate-producing bacteria, Desulfovibrio and Enterococcus faecalis in the feces of patients with colorectal cancer [J].

Balamurugan, Ramadass ;

Rajendiran, Ethendhar ;

George, Sarah ;

Samuel, G. Vijay ;

Ramakrishna, Balakrishnan S. .

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2008, 23 (08) :1298-1303

[9] Gut Microbial Metabolism Drives Transformation of Msh2-Deficient Colon Epithelial Cells [J].

Belcheva, Antoaneta ;

Irrazabal, Thergiory ;

Robertson, Susan J. ;

Streutker, Catherine ;

Maughan, Heather ;

Rubino, Stephen ;

Moriyama, Eduardo H. ;

Copeland, Julia K. ;

Kumar, Sachin ;

Green, Blerta ;

Geddes, Kaoru ;

Pezo, Rossanna C. ;

Navarre, William W. ;

Milosevic, Michael ;

Wilson, Brian C. ;

Girardin, Stephen E. ;

Wolever, Thomas M. S. ;

Edelmann, Winfried ;

Guttman, David S. ;

Philpott, Dana J. ;

Martin, Alberto .

CELL, 2014, 158 (02) :288-299

[10] Molecular analysis of the bacterial microbiota in the human stomach [J].

Bik, EM ;

Eckburg, PB ;

Gill, SR ;

Nelson, KE ;

Purdom, EA ;

Francois, F ;

Perez-Perez, G ;

Blaser, MJ ;

Relman, DA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (03) :732-737

← 1 2 3 4 5 6 7 8 9 10 →