Dynamic combinatorial development of a neutral synthetic receptor that binds sulfate with nanomolar affinity in aqueous solution

被引：61

作者：

Rodriguez-Docampo, Zaida ^{[2
]}

Eugenieva-Ilieva, Eugenia ^{[1
]}

Reyheller, Carsten ^{[1
]}

Belenguer, Ana M. ^{[2
]}

Kubik, Stefan ^{[1
]}

Otto, Sijbren ^{[3
]}

机构：

[1] Tech Univ Kaiserslautern, Fachbereich Chem Organ Chem, D-67663 Kaiserslautern, Germany

[2] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

[3] Univ Groningen, Stratingh Inst, Ctr Syst Chem, NL-9747 AG Groningen, Netherlands

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 35期

基金：

英国工程与自然科学研究理事会;

关键词：

ANION-BINDING; SUPRAMOLECULAR CHEMISTRY; MOLECULAR RECOGNITION; HOST-GUEST; COMPLEXATION; ACID; LIBRARIES; SUBUNITS; LIGAND;

D O I：

10.1039/c1cc13451e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Using dynamic combinatorial disulfide chemistry we have developed a new generation of neutral synthetic receptors for anions, based on a macrobicyclic peptide structure. These receptors show an exceptional affinity and selectivity for sulfate ions in aqueous solution [log K-a = 8.67 in 41 mol%( 67 volume%) acetonitrile in water]. The high affinity depends on a delicate balance between rigidity and flexibility in the structure of the receptor.

引用

页码：9798 / 9800

页数：3

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