Taking organelles apart, putting them back together and creating new ones: Lessons from the endoplasmic reticulum

被引：11
作者：
Lavoie, Christine [2 ]
Roy, Line [3 ]
Lanoix, Joel [4 ]
Taheri, Mariam [1 ]
Young, Robin [1 ]
Thibault, Genevieve [1 ]
Farah, Carol Abi [5 ]
Leclerc, Nicole [1 ]
Paiement, Jacques [1 ]
机构：
[1] Univ Montreal, Dept Pathol & Biol Cellulaire, CP 6128,Succ Ctr Ville, Montreal, PQ H3C 3J7, Canada
[2] Univ Sherbrooke, Fac Med, Dept Pharmacol, Sherbrooke, PQ J1H 5N4, Canada
[3] Genome Quebec, Prote Platform, Montreal, PQ, Canada
[4] Caption Prote Inc, Montreal, PQ, Canada
[5] McGill Univ, Montreal Neurol Inst, Dept Neurol & Neurosurg, Montreal, PQ H3A 2B4, Canada
来源：
PROGRESS IN HISTOCHEMISTRY AND CYTOCHEMISTRY | 2011年 / 46卷 / 01期
基金：
加拿大健康研究院;
关键词：
Endoplasmic reticulum; Subcellular fractionation; Cell-free assembly; In vitro and in vivo reconstitution; Electron microscopy; Cytochemistry; Immunocytochemistry; Organelle transplantation; Organelle proteomics; Transformed membranes; Cancer biomarkers; GTP-DEPENDENT FUSION; ISOLATED SUBCELLULAR MEMBRANES; DEVELOPING RAT HEPATOCYTE; INNER NUCLEAR-MEMBRANE; TO-GOLGI TRANSPORT; IN-VITRO; ROUGH MICROSOMES; PROTEIN-SYNTHESIS; LIVER MICROSOMES; SYNTAXIN;
D O I：
10.1016/j.proghi.2011.04.001
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The endoplasmic reticulum (ER) is a highly dynamic organelle. It is composed of four subcompartments including nuclear envelope (NE). rough ER (rER). smooth ER (sER) and transitional ER (tER). The subcompartments are interconnected, can fragment and dissociate and are able to reassemble again. They coordinate with cell function by way of protein regulators in the surrounding cytosol. The activity of the many associated molecular machines of the ER as well as the fluid nature of the limiting membrane of the ER contribute extensively to the dynamics of the ER. This review examines the properties of the ER that permit its isolation and purification and the physiological conditions that permit reconstitution both in vitro and in vivo in normal and in disease conditions. (C) 2011 Elsevier GmbH. All rights reserved.
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页码：1 / 48
页数：48
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