Medical progress: The challenge of HIV-1 subtype diversity

被引：400

作者：

Taylor, Barbara S. ^{[1
]}

Sobieszczyk, Magdalena E. ^{[1
]}

McCutchan, Francine E. ^{[1
]}

Hammer, Scott M. ^{[1
]}

机构：

[1] Columbia Univ, Med Ctr, Dept Med, Div Infect Dis, New York, NY 10032 USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2008年 / 358卷 / 15期

关键词：

D O I：

10.1056/NEJMra0706737

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

HIV-1 has evolved multiple mechanisms to elude immune control. The view of virus as classifiable into distinct subtypes needs to reflect the reality of the constant emergence of new strains. This review discusses the implications of subtype diversity in HIV-1 for possible differential rates of disease progression, responses to antiretroviral therapy (including the development of resistance), and vaccine development. Copyright © 2008 Massachusetts Medical Society. All rights reserved.

引用

页码：1590 / 1602

页数：13

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