Administration and clearance of amphotericin B during high-efficiency or high-efficiency/high-flux dialysis

Administration and clearance of amphotericin B infused during high-efficiency or high-efficiency/high-flux dialysis were studied In two end-stags renal disease patients requiring systemic antimycotic treatment for fungal peritonitis, Amphotericin B concentrations were measured in the arterial and venous dialysis ports as well as in the ultrafiltrate. Amphotericin B is poorly dialyzable while administered during hemodialysis sessions with high-efficiency (CA 210) or high-efficiency/high-flux (CT 190 G) membranes. Amphotericin B Infusion during hemodialysis was well tolerated and can be administered conveniently In an outpatient dialysis setting, avoiding prolonged hospitalization for parenteral antifungal therapy. (C) 2001 by the National Kidney Foundation, Inc.