c-Met Signaling as a Therapeutic Target in Head and Neck Cancer

被引：11

作者：

Centuori, Sara M. ^{[1
,2
]}

Bauman, Julie E. ^{[3
,4
]}

机构：

[1] Univ Arizona, Coll Med, Dept Med, Tucson, AZ USA

[2] Univ Arizona, Canc Ctr, Tucson, AZ USA

[3] George Washington Univ, Dept Med, Sch Med & Hlth Sci, Washington, DC USA

[4] George Washington Univ, George Washington Canc Ctr, Washington, DC USA

来源：

CANCER JOURNAL | 2022年 / 28卷 / 05期

关键词：

c-Met; head and neck squamous cell carcinoma; HGF; HEPATOCYTE GROWTH-FACTOR; SQUAMOUS-CELL CARCINOMA; PHASE-II TRIAL; CAR-T-CELLS; TUMOR-ASSOCIATED FIBROBLASTS; LUNG-CANCER; TYROSINE KINASE; SCATTER FACTOR; DENDRITIC CELLS; FACTOR-RECEPTOR;

D O I：

10.1097/PPO.0000000000000619

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Despite a dearth of activating driver mutations in head and neck squamous cell carcinoma (HNSCC), aberrant activation of the oncogenes, epidermal growth factor receptor (EGFR), and c-Met is near-universal in human papillomavirus (HPV)-negative disease. Although EGFR activation drove the successful development of the anti-EGFR monoclonal antibody cetuximab in HNSCC, no c-Met-targeting therapy has gained regulatory approval. Inhibition of the c-Met pathway may subvert oncogenesis within the tumor-intrinsic compartment, blocking tumoral proliferation, invasion, migration, and metastasis, or the tumor-extrinsic compartment, modulating the immunosuppressive tumor microenvironment. This review discusses the rationale and current drug development strategies for targeting c-Met or its exclusive ligand hepatocyte growth factor (HGF) in HNSCC.

引用

页码：346 / 353

页数：8

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